MỘT SỐ ĐẶC ĐIỂM HUYẾT HỌC MÁU NGOẠI VI Ở BỆNH NHÂN UNG THƯ VÒM MŨI HỌNG

Abstract

Nasopharyngeal carcinoma (NPC) is a malignant disease with high frequency in head and neck cancers. Objective: To evaluate some hematological characteristics of peripheral blood in patients with nasopharyngeal carcinoma. Subjects and Methods: A cross-sectional study on 44 patients with nasopharyngeal carcinoma diagnosed by histopathology and 46 healthy people of same-sex and age. Result: The ratio between males and females is 2:1, the age with a high frequency of disease is 41-60-year-old, and 65.9% of the patients are diagnosed in late stages III-IV. Cell count and frequency of white blood cells, neutrophil of NPC patients 4.51 ± 1.26G/L; 60.87 ± 7.78% are significant higher than those of healthy control people 3.66 ± 1.17G/L; 55.35 ± 7.22% with p < 0.001. Cell count and frequency of lymphocyte of NPC patients 1.95 ± 0.43 G/L; 26.53 ± 6.90% is significant lower than that of healthy control people 2.27 ± 0.69 và 33.09 ± 7.73% with p < 0.001. NLR index of NPC patients 2.46 ± 1.05 is higher than that of healthy control people. Moreover, decreased monocyte and increased basophile in NPC patients compared to healthy control people. Other tests, including red blood cell count, hemoglobin, hematocrit, and platelet cell count, are no significant difference between patients and healthy control. Conclusion: There is an increase in the quantity and frequency of neutrophiles while a decrease in lymphocyte quantity and frequency leads to the rise of NLR in NPC patients compared to healthy control. Other characteristics, including red blood cell count, hemoglobin, hematocrit, and platelet quantity, are no significant difference between patients and healthy control.