MALIGNANT PHYLLODES TUMOR WITH LUNG METASTASES - DOCUMENT REVIEW AND CASE REPORTS

Cung Văn Công1,
1 National Lung Hospital

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Abstract

The World Organization (WHO) 2018 histopathological classification of breast tumors, in the group Fibroepithelial Tumor and Hamartomas there are Phyllodes tumors (tumors have original of epithelial fibers cell). This type of breast tumor is uncommon, accounting for <1% of all breast tumors. They can appear in 3 forms: Benign, marginal and malignant; and is usually found in women between the ages of 42 and 45. Approximately 16% to 30% of Phyllodes tumors are malignant. In the breast, malignant neoplasms usually grow rapidly but often metastasize late, mainly to the lungs. We report a case of Phyllodes tumor in a 62-year-old female patient, who underwent mastectomy of breast tumor 15 years ago (histopathology is unknown), and now has lung metastases and pneumothorax. The patient underwent laparoscopic surgery to treat pneumothorax and remove the lung tumor for pathology. The results of histopathology and immunohistochemistry confirmed phyllodes tumor lung metastasis.

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References

1. Moon SH, Jung JH, Lee J, et al. Complete remission of giant malignant phyllodes tumor with lung metastasis: A case report. Medicine (Baltimore). 2019 May;98(22):e15762. doi: 10.1097/MD.0000000000015762.PMID: 31145295
2. Khan SA, Badve S. Phyllodes tumors of the breast. Curr Treat Options Oncol. 2001 Apr;2(2):139-47. doi: 10.1007/s11864-001-0056-y. PMID: 12057132
3. Nakamura S, Goto T, Nara S, et al. Pure ground glass opacity (GGO) on chest CT: a rare presentation of lung metastasis of Malignant Phyllodes Tumor. Breast Cancer. 2020 Nov;27(6):1187-1190. doi: 10.1007/s12282-020-01122-y. Epub 2020 Jun 23.PMID: 32578005
4. Sha H, Liu Q, Xie L, Shao J, et al. Case Report: Pathological Complete Response in a Lung Metastasis of Phyllodes Tumor Patient Following Treatment Containing Peptide Neoantigen Nano-Vaccine. Front Oncol. 2022 Feb 8;12:800484. doi: 10.3389/fonc.2022.800484. eCollection 2022.PMID: 35211402
5. Kuo CY, Lin SH, Lee KD, et al. Transcatheter arterial chemoembolization improves the resectability of malignant breast phyllodes tumor with angiosarcoma component: a case report. BMC Surg. 2019 Jul 27;19(1):100. doi: 10.1186 /s12893-019-0562-0.PMID: 31351458
6. Koukourakis IM, Zygogianni A, Kouloulias V, et al. Successful Treatment of a Locally Recurrent and Metastatic Malignant Phyllodes Tumor with Accelerated Radiotherapy and Nab-Paclitaxel, Cisplatin, and Liposomal Doxorubicin Chemotherapy. Chemotherapy. 2021;66(3):82-86. doi: 10.1159/000517246. Epub 2021 Jul 7.PMID: 34233328
7. Morisaki T, Noda S, Ishihara S, et al. A Case of a Malignant Phyllodes Tumor in the Breast with Lymph Node Metastasis. Gan To Kagaku Ryoho. 2021 Mar;48(3):437-439.PMID: 33790180
8. Sanguinetti A, Bistoni G, Calzolari F, et al. Cystosarcoma phyllodes with muscular and lymph node metastasis. Our experience and review of the literature. Ann Ital Chir. 2012 Jul-Aug;83(4):331-6. PMID: 22610081