NHẬN XÉT MỘT SỐ TÁC DỤNG KHÔNG MONG MUỐN KHI ĐIỀU TRỊ NGỘ ĐỐC CẤP METHANOL BẰNG ETHANOL ĐƯỜNG UỐNG

Abstract

Objective: to assess the adverse effects of oral ethanol regimen in the treatment of the patients with acute methanol intoxication. Subjects and methods: The adverse effects were evaluated in 61 patients with acute methanol poisoning who were indicated ethanol 20% orally according to the protocol at Poison Control Center (PCC) of Bach Mai Hospital from October 2016 to July 2018. Results: Average age was 46.7 ± 15 (16-71) years old, male accounted for 93.4%. Average age: 46.7 ± 15 years, male 93.4%. The poisonings mainly were orally (98.4%), however, there was one patient through respiratory tract (1.6%). The median of blood methanol concentration was 126 mg/dL. The side effects when using oral ethanol were central nervous system depression (18.2%), central nervous stimulation (18.2%). In addition, on the digestive system, nausea (31.8%), vomiting (10%), and increased transaminases (14.6) were common manifestations. Only one patient exhibited gastritis (1.6%), no patient had gastrointestinal bleeding and acute pancreatitis. No patient had complications with aspiration pneumonia hypoglycemia, or electrolyte disturbances. Conclusions: Research shows the main undesirable effects when using Ethanol as a specific antidote for patients with acute methanol poisoning.