HIỆU QUẢ ĐIỀU TRỊ CỦA KHÁNG SINH NHÓM CARBAPENEM TRÊN BỆNH NHÂN NHIỄM KLEBSIELLA PNEUMONIAE TẠI BỆNH VIỆN ĐA KHOA TRUNG ƯƠNG CẦN THƠ

Abstract

Background: Klebsiella pneumoniae is one of the bacteria that cause serious nosocomial infections. The study was conducted to evaluate the effectiveness of the antibiotic (KS) Carbapenem on patients infected with Klebsiella pneumoniae at Can Tho Central General Hospital. Methods: A cross-sectional study surveying 256 medical records at the Intensive Care Unit (ICU) and Respiratory Department in the period of 2018 - 2020. Results: Treatment success rate 38.7% and failure rate 60.3%. The older the age group, the risk of not responding to carbapenem was 2.98 times (95% CI: 1.4 – 6.6). Patients with a hospital stay lasting ≥ 14 days had a 5.4-fold increased risk of non-response to carbapenem (95% CI: 2.3 – 12.7). Patients with mechanical ventilation had a 15.9 times higher risk of not responding to carbapenem (95% CI: 1.2 – 193.04). Patients with prolonged antibiotic use did not respond to carbapenem 2.5 times (95% CI: 1.03 – 6.1). Patients using low doses of carbapenem had a 1.9-fold increased risk of non-response (95% CI: 1.0 - 3.7). Patients switching regimens in treatment did not respond to carbapenem 3.5 times (95% CI: 1.6 - 7.7). Conclusion: The use of carbapenem antibiotics must be based on microbiological evidence and the patient's condition in order to improve the effectiveness of reducing antibiotic resistance.