THỰC TRẠNG SỬ DỤNG KHÁNG SINH TRONG ĐIỀU TRỊ NHIỄM KHUẨN GRAM ÂM ĐA KHÁNG TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI

Abstract

Background: Multi-antibiotic resistance is an urgent problem for the global health sector. Objective: Characterization of antibiotic use in the treatment of multi-resistant Gram-negative infections. Materials and methods: A cross-sectional descriptive design, recording the laboratory characteristics of 237 patients in the Department of Emergency Medicine and Endocrinology-Respiratory Medicine of Hanoi Medical University Hospital from January 2021 to December 2021. Results: The mean age of the patients was 73.2 ± 15.8 years old. The average number of hospital days for all patients was 18.3 ± 12.4 days. More than 60% of patients received a combination of 2 antibiotics both before and after the antibiogram. There were 232/237 hospitalized patients receiving initial antibiotic treatment. The concordance with the antibiogram before the antibiogram was 25.0%, and after the antibiogram was 61.6%. Among the patients taking antibiotics, 62.5% had to change after having the antibiogram, and 35.4% did not have to change. Mechanical ventilation, ICU admission, and appropriate antibiotic treatment are factors related to treatment outcome (p<0.05). Conclusion: Antibiotics used in the treatment of multidrug-resistant gram-negative infections are mostly consistent with reference guidelines.