TUÂN THỦ ĐIỀU TRỊ TIỆT TRỪ HELICOBACTER PYLORI VÀ CÁC YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN ĐIỀU TRỊ NGOẠI TRÚ TẠI BỆNH VIỆN QUẬN 2, TP. HCM

Abstract

Introduction: H. pylori has been proved to be related to duodenal and gastric ulcers, which can lead to gastrointestinal bleeding, perforation and gastric cancer. In Vietnam, the prevalence of H. pylori infection in patients with peptic ulcer is from 60 to 80%.  However, the effect of H. pylori treatment gradually decreased from 90% in the 1990s to 60-70% after 2010. This rate is related to antibiotic resistance due to the non-compliance of patients. Subjects and method: We recruitedin our prospective, cross-sectional study 249 adults with H. pyloriwho were undergoing an eradication treatment for the first-time. Patients with HP(+)will be invited in study and asked for socio-demographic and clinical information. After 2 weeks of medication, a follow-up visit has been made and the compliance would be assessed. Compliance assessment according to the WHO definition includes 2 criteria: drug compliance and non-alcohol and tobacco compliance. Results: Therates of drugs compliance, nonalcohol-tobacco compliance, and general compliance were respectively 84.74%, 95.58% and 83.13%. There was a statistically significant association between adherence to treatment and: female sex (RR = 1.16; p = 0.011), detected bygeneral check (RR = 1.17; p = 0.033), having comorbidities (RR = 1.17; p = 0.012), be counseled (RR = 1.16; p = 0.016), no history of smoking (RR = 1.87; p < 0.001) and no history of drinking (RR = 2.27; p <0.019). Conclusion: Low compliance indicates a need for improvement in health education and counseling.