PHÂN TÍCH TÌNH HÌNH KÊ ĐƠN THUỐC CHO NGƯỜI CAO TUỔI BẰNG TIÊU CHUẨN BEERS, TIÊU CHUẨN STOPP/START THÔNG QUA HOẠT ĐỘNG DƯỢC LÂM SÀNG TẠI BỆNH VIỆN ĐA KHOA HUYỆN NGHI LỘC

Abstract

 Objective: To analyze Potential Inappropriate Prescribing in the elderly at Nghi Loc General Hospital by using Beers 2019 criteria and STOPP/START version 2 criteria. Investigate of the association between Potentially Inappropriate Medication (PIM) and Adverse drug event (ADE). Methods: Observational/Forward study. Subjects: Patients ≥ 65 years admitted to the departments of Nghi Loc District General Hospital. Results: There were 255 patients, the rate of PIM according to Beers and STOPP criteria was 45.49% and 48.63%, respectively; the rate of PPO according to START was 28.63%. The most common PIMs are long-acting benzodiazepines and NSAIDs. Common PPOs: vitamin D, calcium; platelet aggregation inhibitors/statins. Factors affecting the likelihood of encountering PIM according to Beers include the number of drugs used in the treatment (≥10 drugs) with OR=4,116 (p<0.001). Factors affecting the likelihood of meeting PIM according to STOPP include Charlson Comorbidity Index CCI (1-2 points) with OR=2,185 (p=0.043) and the number of drugs used in the treatment ≥10 drugs with OR=4.722 (p<0.001). There was a relationship between PIM and ADE (p=0.015). Conclusion: The rate of PIM according to Beers and STOPP criteria was 45.49% and 48.63% respectively; the rate of PPO according to START was 28.63%. Reducing the number of drugs administered may be the first step to decrease PIMs in elderly patients and to prevent ADE.