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EXTERNAL EVALUATION OF POPULATION PHARMACOKINETIC MODELS FOR VANCOMYCIN IN ADULT PATIENTS TREATED AT SAINT PAUL HOSPITAL
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Abstract
Objective: To improve the quality of TDM vancomycin service at Saint Paul General Hospital, we screened and determined a suitable population pharmacokinetic (POP PK) model for concentration data from Saint Paul General Hospital patients, leading to a precise dosing correction tool using the Bayesian method. Methods and subjects: The predictive ability of vancomycin POP PK models was evaluated using a data set of vancomycin concentrations collected at Saint Paul General Hospital from a group of patients undergoing TDM vancomycin. Results: The performance of the tested models varied with our data set. The best fit model is Yamamoto's vancomycin POP PK model, which was published in 2009, with a mean absolute prediction error (MAPE) of 9.96% - excellent prediction level, and mean prediction error (MPE) of 0.637 mg/l (<2.5 mg/l –Limit of quantification). Conclusion: Yamamoto's model, published in 2009, is the most appropriate for the patient population at Saint Paul General Hospital. These findings could be utilized to create a future Bayesian dosage correction tool.
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Keywords
vancomycin, TDM, POP PK, external validation
References
2. Buelga D. S., del Mar Fernandez de Gatta M., et al. (2005), "Population pharmacokinetic analysis of vancomycin in patients with hematological malignancies", Antimicrob Agents Chemother, 49(12), pp. 4934-41.
3. Cheng Y., Wang C. Y., et al. (2021), "Can Population Pharmacokinetics of Antibiotics be Extrapolated? Implications of External Evaluations", Clin Pharmacokinet, 60(1), pp. 53-68.
4. Goti V., Chaturvedula A., et al. (2018), "Hospitalized Patients With and Without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis", Ther Drug Monit, 40(2), pp. 212-221.
5. Lewwis Colin David (1982), "Industrial and business forecasting methods: A practical guide to exponential smoothing and curve fitting", pp.
6. Medellín-Garibay S. E., Ortiz-Martín B., et al. (2016), "Pharmacokinetics of vancomycin and dosing recommendations for trauma patients", J Antimicrob Chemother, 71(2), pp. 471-9.
7. Thomson A. H., Staatz C. E., et al. (2009), "Development and evaluation of vancomycin dosage guidelines designed to achieve new target concentrations", J Antimicrob Chemother, 63(5), pp. 1050-7.
8. Yamamoto M., Kuzuya T., et al. (2009), "Population pharmacokinetic analysis of vancomycin in patients with gram-positive infections and the influence of infectious disease type", J Clin Pharm Ther, 34(4), pp. 473-83.