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Date Published: 23/06/2022
Abstract Views: 158
Views PDF: 96
DOI: https://doi.org/10.51298/vmj.v515i2.2811
Issue
Vol. 515 No. 2 (2022)
Section
Các bài báo
How to Cite
Văn Hùng, P. ., & Thị Kiều, N. . (2022). CHARACTERISTICS OF VITAMIN B1 CONCENTRATION IN THE BLOOD OF TYPE 2 DIABETES PATIENTS AT HANOI MEDICAL UNIVERSITY HOSPITAL. Vietnam Medical Journal, 515(2). https://doi.org/10.51298/vmj.v515i2.2811

CHARACTERISTICS OF VITAMIN B1 CONCENTRATION IN THE BLOOD OF TYPE 2 DIABETES PATIENTS AT HANOI MEDICAL UNIVERSITY HOSPITAL

Phạm Văn Hùng1,, Nguyễn Thị Kiều1
1 National Institute For Control of Vaccine and Biologicals, Ministry of Health

Main Article Content

Abstract

Objective: To describe the blood levels of vitamin B1 in patients with type 2 diabetes who visited the Hanoi Medical University Hospital. Methodology: A cross-sectional description with control was applied in 227 patients in the study group and 231 patients in the control group. Results: The plasma thiamin concentration in the group of patients with type 2 diabetes was statistically significantly lower than in the control group. The thiamin reduction rate of the study group was 84.1%. There were no differences in thiamin concentrations in men and women nor in the rate of thiamin reduction. There was no difference in thiamin concentrations in the age groups. The rate of thiamin decrease tended to decrease with age, but the difference was not statistically significant with p<0.05. Conclusion: Thiamin concentration decreased significantly compared with the control group (45.6 pg/ml vs 63.9 pg/ml) (p<0.001). The proportion of patients with decreased thiamin in general: 84.1%. There was no relationship between plasma thiamin concentrations in patients with type 2 diabetes by sex and age.

Article Details

Keywords

plasma thiamin, type 2 diabetes, vitamin B1

References

1. Alam S, Riaz S, Akhtar M, et al. (2012) “Effect of High Dose Thiamine Therapy on Risk Factors in Type 2 Diabetes”. Journal of Diabetes & Metabolism, pp.1/15-15/15.
2. Hobara R, Ozawa K, Okazaki M, et al. (1981) “Ralationship between thiamine and glucose levels in diabetes mellitus”. Japan J Pharmacol, pp.1098-1100.
3. Daghri N, Alharbi M, Wani K, et al. (2015) “Biochemical changes correlated with blood thiamine and its phosphate esters levels in patiens with diabetes type 1 (DMT1)”. Int J Clin Exp Pathol, 8(10), pp.13483-13488.
4. Alkhalaf A, Klooster A, Oeveren W, e al. (2010) “A Double – Blind, Randomized, Placebo – controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic nephropathy”. Diabetes Care, pp.1598-1601.
5. Yuka K, Shirakawa H, Yamane K, et al. (2008). “Prevention of incipient diabetic cardiomyopathy by high-dose thiamine”. The Journal of Toxicological Sciences (J.Toxicol. Sci), 33(4), pp.459-472.
6. Anwar A, Azmi MA, Siddiqui JA, et al (2020). “Thiamine level in type I and type II diabetes mellitus patients: A Comparative study focusing on hematological and biochemical evaluations”. Cureus, 12(5), pp.1/11-11/11.
7. Nguyễn Thu Phương, Hoàng Trung Vinh (2021) Nồng độ thiamin huyết tương ở bệnh nhân đái tháo đường týp 2, Nội tiết và Đái tháo đường, no.45 - tr.7-10 - ISSN.1859-4727
8. Nix A, Zirwes R, Bangert V, et al. (2014). “Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy”. Diabetes Research and Clinical Practice, pp.157- 165.
9. Marrs C (2015). “Diabetes and Thiamine: A Novel treatment opportunity”. Hormones Matter, pp.1/10- 10/10.
10. Esther G, Nanne K (2014). “Thiamine”, Diapedia the living textbook of diabetes, no 8, pp.1/4-4/4.
11. Richard H.Mann, (2018) “Thiamine deficiency and diabetic polyneuropathy”. Compelling evidence for an interrelationship, 10(11), pp.1-19.