KẾT QUẢ ĐIỀU TRỊ HỘI CHỨNG THỰC BÀO TẾ BÀO MÁU BẰNG PHÁC ĐỒ HLH 2004 TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objective: To evaluate the effective treatment of HLH 2004 guideline in patients with hemophagocytic lymphohistiocytosis in national children hospital from 6/2016 to 5/ 2021. Method: We conducted a retrospective study in 122 HLH children who were hospitalized from 6/2016 to 5/ 2021 at Clinical Hemotology Department – National Children Hospital. All patients were treated with HLH- 2004 protocol. The outcome of patients was clasified into groups: non – active disease, active disease, reactivation of disease and death group. Results: A total of 122 patients were enrolled, with the rate fatality in the initial period was 12,3% (15/122), at the end of study was 28,7% (35/122). The 3 – year and 5 – year overall survival (OS) rate of all patients was 71,2% and 70,1%. The 3 – year and 5 – year event free survival (EFS) rate of all patients was 68,5% and 67,4%. Conclusion: OS rate was relatively high with 5 – year overall survival (OS) rate of all patients was 71,2% so we need to continue treating HLH- 2004 protocol early for HLH patient to reduce mortality rate.