TÌM HIỂU TÌNH TRẠNG BỘC LỘ QUÁ MỨC HER2 VỚI TYP MÔ BỆNH HỌC CỦA UNG THƯ BIỂU MÔ DẠ DÀY

Abstract

Stomach cancer is one of the most common cancers, and is a major problem for public health. The detection of  Her2 overexpression in gastric adenocarcinoma mean very important decision in whether or not to use the targeted therapies for patients in the late stage. The study was done to main objective:  Connect Her2 overexpression with histopathological characteristics of gastric carcinoma according to the 2019 WHO classification. Object and research methods: descriptive cross-sectional study on 142 cases diagnosed as gastric cancer is resected the partial or the entire stomach at the Hanoi Oncology Hospital from January 2015 to December 2020. Results: of 142 patients, 33 patients with the excessive Her2 overexpression positive. According to the 2019 histopathological classification of the World Health Organization, met most common is adenocarcinoma with 91 cases (64,1%). The results of the excessive Her2 overexpression in adenocarcinoma is 24/91 (26,4%), papillary carcinoma is 5/17 (29,4%), mucinous carcinoma is 1/18 (5,6%), poorly cohesive carcinoma is 2/11 (18,2%), adenocarcinoma with mixed subtypes is ¼ (25,0%),  is . There are no cases positive for Parietal cell carcinoma. Conclusion: The Her2 overexpression positive rate of gastric carcinoma was 23,2%. There is no relation between the excessive Her2 overexpression with position, morphology and histology be classified by the World Health Organization, 2019.