MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG VÀ XÉT NGHIỆM CỦA CÁC THỂ BỆNH HỘI CHỨNG RỐI LOẠN SINH TỦY NGUYÊN PHÁT

Abstract

A cross-sectional descriptive study was carried out to investigate some clinical and laboratory features of primary myelodysplastic syndromes according to WHO-2008 classification. The study was conducted on 104 patients diagnosed with primary myelodysplastic syndrome who were admitted to the hospital for the first time at the National Institute of Hematology and Blood Transfusion. The study results showed that the most common types of diseases in primary myelodysplastic syndrome according to WHO-2008 classification was RCMD (53.8%); followed by RAEB-1 form (23.1%); RAEB-2 (14.4%); rare forms of RA, RN, RT, MDS-U and Del-5q. Anemia symptoms were found in most of the patients (95.2%) of which 16.3% were severe anemia. 26.9% of patients had bleeding, mainly subcutaneous bleeding. 13.5% of patients presented with fever/infection. Peripheral blood decreased one, two, or all three cell lines. Peripheral blood morphological disorders were expressed in all three cell lines: erythrocyte polymorphism, irregular size, specific decrease or loss of protoplasmic neutrophils, macrocytic or stunted platelets.