CÁ NGỰA VẰN (DANIO RERIO) - MÔ HÌNH ĐỘNG VẬT TRONG NGHIÊN CỨU Y HỌC VÀ PHÁT TRIỂN THUỐC: NHỮNG ƯU ĐIỂM NỔI BẬT

Abstract

Preclinical testing has been required for a new drug or biological therapeutics using an animal model. To assess the toxicity and pharmacological activities, different animal models such as mice or rats, rabbits, dogs, cows have been used. In there, mice or rats are traditional and common animal models that present various advantages. However, zebrafish are an outstanding vertebrate model to preclinical testing with different advantages such as similar genome to humans, the rapid development compares to other animals, a large number of fish or embryos per mating. In this review, we introduce zebrafish husbandry and embryos collection, the advantages of the zebrafish model, the method to assess the toxicity testing and   pharmacological activities testing using the zebrafish model.