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EVALUATION OF SPERM RETRIEVAL RATE IN NON-OBSTRUCTIVE AZOOSPERMIA PATIENTS WITH AZF DELECTIONS
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Abstract
Objectives: To investigate the general characteristics of azoospermia patients with AZF deletions, to evaluate the rate of sperm retrieval in infertile men with AZF deletion. Subjects and methods: A retrospective study was conducted on 26 men with AZF deletions in nonobstructive azoospermia patients at the Andrology and Fertility Hospital of Hanoi from December 2016 to December 2021. Results: The mean age of the study patients was 32.5±5.03 years old. The youngest is 26 years old, the oldest is 56 years old. The mean time of infertility of the study group was 3.32±1.34, the shortest period of time was 1 year and the longest was 5 years. For cases of AZF deletions, the rate of sperm retrieval in AZFa, AZFb, AZFc deletion was 0%, 54.55% and 42.86%, respectively. Conclusion: This study reinforces the superiority of the micro TESE technique in the group of patients with non-obstructive azoospermia as well as shows the rate of sperm retrieval in each group of AZF deletions.
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Keywords
AZF, AZFa, AZFb, AZFc, AZFd, microdeletion, nonobstructive azoospermia
References
2. D. S. Irvine, “Epidemiology and aetiology of male infertility,” Hum. Reprod., vol. 13, no. suppl 1, pp. 33–44, Apr. 1998, doi: 10.1093/humrep/ 13.suppl_1.33.
3. M. Wosnitzer, M. Goldstein, and M. P. Hardy, “Review of Azoospermia,” Spermatogenesis, vol. 4, no. 1, p. e28218, Jan. 2014, doi: 10.4161/ spmg.28218.
4. R. Flannigan, P. V. Bach, and P. N. Schlegel, “Microdissection testicular sperm extraction,” Transl. Androl. Urol., vol. 6, no. 4, pp. 745–752, Aug. 2017, doi: 10.21037/tau.2017.07.07.
5. S. Esteves, R. Miyaoka, J. Orosz, and A. Agarwal, “An update on sperm retrieval techniques for azoospermic males,” Clinics, vol. 68, no. S1, pp. 99–110, Mar. 2013, doi: 10.6061/ clinics/2013 (Sup01)11.
6. M. Kimura et al., “Balance of Apoptosis and Proliferation of Germ Cells Related to Spermatogenesis in Aged Men,” J. Androl., vol. 24, no. 2, pp. 185–191, 2003, doi: 10.1002/j.1939-4640.2003.tb02661.x.
7. Trịnh Thế Sơn, “Nghiên cứu đặc điểm hình thái ống sinh tinh của bệnh nhân không có tinh trùng trong tinh dịch, đánh giá hiệu quả một số phương pháp hỗ trợ sinh sản.” Học viện Quân y, 2011.
8. P. N. Schlegel, “Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision,” Hum. Reprod. Oxf. Engl., vol. 14, no. 1, pp. 131–135, Jan. 1999, doi: 10.1093/ humrep/14.1.131.