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MICROSATELLITE INSTABILITY STATUS AND CORRELATE WITH HISTOPATHOLOGY IN COLORECTAL CANCER
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Abstract
Introduction: Colorectal cancer (CRC) is one of the most common malignancies in the world. Microsatellite instability (MSI) is a hallmark feature of Lynch syndrome cancers and occurs in about 12-15% of sporadic colorectal cancers as well. Determining the status of MSI helps screen Lynch syndrome, a predictive marker for response to chemotherapy as well as immunotherapy. Objective: Evaluate MSI status in CRC and correlate with histopathology. Methods: 97 patients with colorectal cancer were studied by Immunohistochemistry method with markers MLH1, PMS2, MSH2, MSH6. Result: MSI rate 12.4%. Age <50 is more common in MSI tumor (41.7%) than Microsatellite stability (MSS) tumor (30.6%), high rate in proximal conlon 83.3%. Mucinous type 50%, poor differentiation 66.7%, tumor infiltrating lymphocytes 58,3% are common features in MSI tumor. Conclusion: Colorectal cancer (CRC) with MSI status has distinctive clinicopathologic features, such as young patients under 50, proximal colon, mucinous and medullary phenotypes, poor differentiation and tumor infiltrating lymphocytes. Determining the status of MSI helps screen Lynch syndrome, a predictive marker for response to chemotherapy as well as immunotherapy.
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Keywords
Microsatellite, Lynch syndrome, Immunohistochemistry, Histopathology
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