MỐI TƯƠNG QUAN GIỮA ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG Ở BỆNH NHÂN NHƯỢC CƠ THỂ MẮT

Abstract

Ocular Myasthenia Gravis is a neuromuscular disorder that is often the beginning of generalized myasthenia gravis. Objectives: To analyze the correlation between the clinical and subclinical characteristics in patients with ocular myasthenia gravis. Subjects and methods: We studied 43 patients with ocular myasthenia gravis treated at Bach Mai Hospital's Neurological Center. Results: Females accounted for 65.1%, males 34.9%, and the mean age was 44.7 ± 14.3. Test neostigmine was positive at 88.4%. The repetitive nerve stimulation test (KTTKLT) was positive for the eye myasthenia gravis at 30.8%, for the generalized myasthenia gravis group at 80%. Anti-acetylcholine receptor (AChR Ab) antibody test was positive for ocular myasthenia gravis at 76.9%, with the generalized myasthenia gravis at 93.3%. There was a correlation between disease duration, ptosis location, and the type of myasthenia gravis (p<0.05), respectively OR (95%CI) was 15.7 (1.8-136.6) and 7,4 (1.7-31.5%). There is a correlation between KTTKLT, the AChR Ab test, and the severity of myasthenia gravis according to Osserman's classification (p<0.05), the corresponding OR (95%CI) is 9.0 (2.1 - 39.5) and 4.2 (1.2 - 28.9). Conclusion: The ophthalmic myasthenia gravis with a positive diagnostic test is still low, so it is necessary to distinguish it from other diseases.