GIÁ TRỊ CỦA XÉT NGHIỆM HCV CORE ANTIGEN TRONG SÀNG LỌC SIÊU VI VIÊM GAN C

Abstract

Objective: To determine the sensitivity and specificity of the HCV core Antigen test and to evaluate the correlation between the concentration of HCV core Antigen and HCV RNA. Subjects and methods: A cross-sectional descriptive study was performed on 102 inpatients and outpatients who came for hepatitis C screening at Nguyen Tri Phuong hospital from February, 2022 to June, 2022. HCV RNA assay was performed by real-time RT-PCR with the IVD NK RTqPCR-Vcquant KIT biological kit, HCV core Ag assay was performed using the CMIA technique with Abbott's reagent kit. HCV RNA test has been used as gold standard. To determine the sensitivity and specificity of the HCV core Antigen test and to evaluate the correlation between the concentration of HCV core Antigen and HCV RNA. Results: The sensitivity and specificity of HCV core Ag were 93, 3% and  91,7%, respectively, at a cutoff value of 3.03 fmol/L, the area under the ROC curve was 0.925 (92,5%) (95% CI 0,92-0,99). There was a mean positive correlation between HCV core Ag and HCV RNA (r= 0,64; p<0,001). Conclusions: HCV core Ag test had high sensitivity and specificity, and had a mean positive correlation with HCV RNA test. This was a valuable test and can be applied in the screening of HCV in Vietnamese patients.