ĐÁNH GIÁ CÁC TÁC DỤNG KHÔNG MONG MUỐN TRONG ĐIỀU TRỊ TRỨNG CÁ THỂ NẶNG BẰNG UỐNG ISOTRETINOIN VỚI LIỀU TÍCH LŨY ĐẠT 60MG/KG VÀ 120 MG/KG

Abstract

Objectives: To evaluate the adverse effects in the treatment of severe acne by oral administration of isotretinoin with cumulative doses of 60mg/kg and 120mg/kg. Method: A retrospective combined prospective study on 60 patients diagnosed with severe acne divided into 2 groups. Results: Cheilitis was the most common side effect, occurring in 95% of patients. Xerosis of the face, which occurred in 70% of patients, was also a common symptom. No patient reported musculoskeletal pain. Only 1 patient had acne flare-ups, and 1 patient had menstrual disorders, accounting for 1,7%. There was no significant difference in clinically adverse effects between the 2 treatment groups. There were no cases of increased liver enzymes during and after treatment. Hyperlipidemia was found in 5 patients with a rate of 8.3%, and the rate of hyperlipidemia in the 2 treatment groups had no significant difference (p = 0.353 > 0.05). Conclusion: The most common adverse effects in both groups were cheilitis, dryness of facial skin, and itching. The less common adverse effects were erythema on the face and photosensitivity. There was no significant difference in clinical side effects between the 2 treatment groups. Isotretinoin has fewer effects on laboratory tests, even at high cumulative doses.