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Date Published: 31/07/2022
Abstract Views: 692
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DOI: https://doi.org/10.51298/vmj.v516i2.3092
Issue
Vol. 516 No. 2 (2022)
Section
Các bài báo
How to Cite
Ngọc Lan Hương, L. ., Thanh Sang, H. ., Ngọc Khôi, N. ., & Như Hồ, N. . (2022). EVALUATION OF DRUG DOSAGE ADJUSTMENT IN PATIENTS WITH RENAL IMPAIRMENT AT GIA DINH PEOPLE’S HOSPITAL. Vietnam Medical Journal, 516(2). https://doi.org/10.51298/vmj.v516i2.3092

EVALUATION OF DRUG DOSAGE ADJUSTMENT IN PATIENTS WITH RENAL IMPAIRMENT AT GIA DINH PEOPLE’S HOSPITAL

Lương Ngọc Lan Hương1, Huỳnh Thanh Sang2, Nguyễn Ngọc Khôi1, Nguyễn Như Hồ1,
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 Ho Chi Minh City University of Technology

Main Article Content

Abstract

Objective: To evaluate the appropriateness in dosage adjustments among inpatients with renal impairment. Materials and methods: A retrospective descriptive study was conducted on patients with CrCl of < 60 mL/min admitted to at Gia Dinh People’s Hospital from January 1st to January 31st 2021. The data collected for analysis included characteristics of patients with renal impairment, appropriateness of dosage adjustments and associated factors. Drug dosage adjustment was considered appropriate if followed information from product summary characteristics. Results: A total of 4150 drug orders were prescribed for 111 patients, of which, 603 (14.5%) required dose adjustments. Approximately 37.1% (225/603) were adjusted inappropriately. Antibiotics were the most common drug class that needed adjustments (65.5%). The rates of inappropriate dose adjustments for levofloxacin, piperacillin/tazobactam and ciprofloxacin were 63.4%; 22.4% and 45.8%, respectively. Geriatrics department, renal comorbidities, and the number of drugs requiring renal dose adjustment were factors that associated with inappropriate dose adjustments. Conclusions: It is necessary to monitor and counsel healthcare professionals about renal dosage adjustments.

Article Details

Keywords

renal impairment, dose adjustment

References

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