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Date Published: 31/07/2022
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DOI: https://doi.org/10.51298/vmj.v516i2.3102
Issue
Vol. 516 No. 2 (2022)
Section
Các bài báo
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Thanh Đức, L. ., & Thị Thu Hoài, B. . (2022). THE RESULTS OF CHAIN OF CHEMOTHERAPY AND ANTI-EGFR DRUGS IN PATIENTS WITH ADVANCED STAGE LUNG CANCER. Vietnam Medical Journal, 516(2). https://doi.org/10.51298/vmj.v516i2.3102

THE RESULTS OF CHAIN OF CHEMOTHERAPY AND ANTI-EGFR DRUGS IN PATIENTS WITH ADVANCED STAGE LUNG CANCER

Lê Thanh Đức1,, Bùi Thị Thu Hoài1
1 Vietnam National Cancer Hospital

Main Article Content

Abstract

Aims: Evaluation of the results of chemotherapy and anti-EGFR drugs in patients with advanced stage lung cancer. Population: The patient was diagnosed stage IV non-small cell lung cancer, received oral erlotinib after 4-6 cycles platinum-containing regimen chemotherapy at National Cancer Hospital from January 2016 to June 2020. Patients and Methods: Retrospective combined prospective study. Results: The overall response rate and disease control rate with platinum-based chemotherapy was 52.4% and 81%, respectively. The overall response rate and disease control rate after 3 months of erlotinib treatment was 33.4% and 93.6%; After 12 months, the overall response rate was 43.0% and the disease control rate was 70.5%. PFS with erlotinib was superior in patients with cutaneous adverse events and response to first-line chemotherapy. Conclusion: Response rates to chemotherapy are higher in patients with EGFR mutations. Progression-free survival with erlotinib is associated with cutaneous adverse events and response to first-line chemotherapy.

Article Details

Keywords

Lung cancer, chemotherapy, anti-EGFR drugs

References

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