Article Sidebar

PDF
Date Published: 22/08/2022
Abstract Views: 221
Views PDF: 172
DOI: https://doi.org/10.51298/vmj.v517i1.3137
Issue
Vol. 517 No. 1 (2022)
Section
Các bài báo
How to Cite
Hoàng Việt, N. ., Tín Nghĩa, T. ., Văn Hưng, L., Kim Đồng, N. ., Đình Thạch, N. ., & Anh Tuấn, P. . (2022). ASSOCIATION BETWEEN MICA/B EXPRESSION AND HPV IN NASOPHARYNGEAL CARCINOMA. Vietnam Medical Journal, 517(1). https://doi.org/10.51298/vmj.v517i1.3137

ASSOCIATION BETWEEN MICA/B EXPRESSION AND HPV IN NASOPHARYNGEAL CARCINOMA

Nguyễn Hoàng Việt1,2,, Trần Tín Nghĩa3, Lê Văn Hưng1, Nguyễn Kim Đồng1, Nguyễn Đình Thạch4, Phạm Anh Tuấn5
1 Hanoi Medical University
2 Center for Gene - Protein Research, Hanoi Medical University
3 Can Tho University of Medicine and Pharmacy
4 Tân Triều Brach of National Cancer Hospital
5 National ENT Hospital

Main Article Content

Abstract

Nasopharyngeal carcinoma (NPC) is one of the most commonly cancer occurred in Southern East Asia, including in Viet Nam. The infection of HPV (human papillomavirus) or the expression of MICA/B- a protein responsible for stimulating immune system to kill cancer cells, both of them recently have been demonstrated that relating to many kinds of human cancers. In this study, we want to figure out the relationship between HPV and MICA/B in NPC cancer. We collected 84 samples of NPC cancer patients to analyze by Nested-PCR and immunohistochemistry (IHC) method. The results showed that 11/84 (13,1%) HPV positive. Moreover, MICA/B expression was significantly decreased in positive HPV group compared to none infected by HPV. Leading to a hypothesis that HPV maybe was an important reason for promoting cancer cells escape from immune system protection. Therefore, understanding the affection of HPV on level of MICA/B expression may further improve treatment on patients with NPC by immunotherapy.

Article Details

Keywords

Nasopharyngeal carcinoma, Human Papillomavirus, MICA/B expression

References

1. Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. The Lancet. 2019;394(10192):64-80. doi:10.1016/S0140-6736 (19)30956-0
2. Asante DB, Asmah RH, Adjei AA, et al. Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana. ScientificWorldJournal. 2017;2017:2721367. doi:10.1155/2017/2721367
3. Lee HM, Okuda KS, González FE, Patel V. Current Perspectives on Nasopharyngeal Carcinoma. Adv Exp Med Biol. 2019;1164:11-34. doi:10.1007/978-3-030-22254-3_2
4. Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24-35. doi:10.1056/NEJMoa0912217
5. Ghadially H, Brown L, Lloyd C, et al. MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue. Br J Cancer. 2017;116(9):1208-1217. doi:10.1038/bjc.2017.79
6. Le HHL, Bi X, Ishizaki A, et al. Human papillomavirus infection in male patients with STI-related symptoms in Hanoi, Vietnam. J Med Virol. 2016;88(6):1059-1066. doi:10.1002/jmv.24422
7. Szymonowicz KA, Chen J. Biological and clinical aspects of HPV-related cancers. Cancer Biol Med. 2020;17(4):864-878. doi:10.20892/j.issn.2095-3941.2020.0370
8. Fang L, Gong J, Wang Y, et al. MICA/B expression is inhibited by unfolded protein response and associated with poor prognosis in human hepatocellular carcinoma. J Exp Clin Cancer Res CR. 2014;33:76. doi:10.1186/s13046-014-0076-7