Article Sidebar

PDF
Date Published: 22/08/2022
Abstract Views: 154
Views PDF: 134
DOI: https://doi.org/10.51298/vmj.v517i1.3146
Issue
Vol. 517 No. 1 (2022)
Section
Các bài báo
How to Cite
Văn Dũng, P. ., Thu Hằng, N. ., Thị Phượng, Đào ., Thị Phương Thảo, T. ., Quang Duật, N. ., Lĩnh Toàn, N., & Văn Tổng, H. . (2022). EVALUATION OF ISG20 SERUM LEVELS IN HEPATOCELLULAR CARCINOMA PATIENTS WITH HBsAg (+). Vietnam Medical Journal, 517(1). https://doi.org/10.51298/vmj.v517i1.3146

EVALUATION OF ISG20 SERUM LEVELS IN HEPATOCELLULAR CARCINOMA PATIENTS WITH HBsAg (+)

Phạm Văn Dũng1,, Ngô Thu Hằng2, Đào Thị Phượng3, Trần Thị Phương Thảo4, Nguyễn Quang Duật5, Nguyen Lĩnh Toàn4, Hoàng Văn Tổng2,4
1 Military Hospital No. 7, General Department of Logistics, Military Region 3, Hai Duong province
2 Vietnam Military Medical University
3 Haiduong Medical Technical University
4 Institute of BioMedicine and Pharmacy, Vietnam Military Medical University
5 Military Hospital 103, Vietnam Military Medical University

Main Article Content

Abstract

Objectives: to evaluate ISG20 protein expression and its clinical and laboratory relevance in patients with HBV infection-associated hepatocellular carcinoma. Material and method: A cross-sectional descriptive study on subjects including 115 patients with hepatocellular carcinoma, 100 liver cirrhosis patients and 120 healthy individuals. Result: serum ISG20 concentrations were determined by ELISA method. The results showed that protein ISG20 concentrations of HCC patients were decreased when compared to LC group and HC group (p<0,05). ISG20 serum levels were associated with AST levels and ages (p<0,05). Conclusion: ISG20 protein decreased expression in HCC patients, related to age and liver enzyme activity.

Article Details

Keywords

ISG20, hepatitis B virus, hepatocellular carcinoma

References

1. GLOBOCAN. [online] Available at, http,//globocan.iarc.fr/Pages /fact_sheets_ cancer.aspx [Accessed 27th July 2015]. 2012
2. Liu Y, Nie H. Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA. Apr 2017;13(4):e1006296. doi: 10.1371/journal.ppat.1006296
3. Van Tong H, Hoan NX, Binh MT, et al. Interferon-stimulated gene 20 kDa protein serum levels and clinical outcome of hepatitis B virus-related liver diseases. Oncotarget. Jun 12 2018;9(45):27858-27871. doi:10.18632/oncotarget.25559
4. Pentecost BT. Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus. J Steroid Biochem Mol Biol. Jan 1998;64(1-2):25-33.
5. Gao M, Lin Y, Liu X, et al. ISG20 promotes local tumor immunity and contributes to poor survival in human glioma. Oncoimmunology. 2019;8(2) :e1534038. doi:10.1080/2162402x.2018.1534038
6. Dai L, Bai L, Lin Z, et al. Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus. Oncotarget. Jul 26 2016;7(30): 47052-47060. doi:10.18632/oncotarget.9720
7. Phạm Thị Hiền Lương. Nghiên cứu đa hình gen TNF-α-308 và TGF-β1-509 ở bệnh nhân ung thư biểu mô tế bào gan có HBsAg dương tính. Học Viện Quân Y; 2020.
8. Phạm Văn Dũng, Nguyễn Quang Duật, Hoàng Văn Tổng, et al. Nghiên cứu biểu hiện của ISG20 ở bệnh nhân ung thư biểu mô gan có liên quan đến HBV. Journal of 108 - Clinical Medicine and Phamarcy. 2021;16(1)