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SINGLE BLASTOCYST TRANSFER: AN EFFECTIVE SOLUTION TO MINIMIZE THE RISK OF MULTIPLE PREGNANCY IN WOMEN UNDER 35
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Abstract
Objective: Comparison of pregnancy outcomes and multiple pregnancy rates between single blastocyst transfer and double blastocyst transfer in frozen embryo transfer cycle of patients under 35 years of age. Methods: Patients with frozen blastocyst transfer under 35 years of age and with good quality embryos were divided into 2 groups, group 1 (study group) included 78 patients with 1 blastocyst transfer, group 2 (control group) included 85 patients with 2 blastocysts transfer. Evaluation of pregnancy rate, embryo implantation rate, ongoing pregnancy rate, live birth rate, miscarriage rate, preterm birth rate and multiple pregnancy rate of 2 groups. Results: There were no statistically significant differences between pregnancy rate (56,41% vs 56,47%; p = 0,99), clinical pregnancy rate (51,2% vs 52,9%; p = 0,83), ongoing pregnancy rate (44,8% vs 44,7%; p = 0,98) and live birth rate (44.8% vs 44,7%; p = 0,98) between the 2 groups. However, the group that transferred 2 blastocysts had a higher multiple pregnancy rate and premature birth rate than the group that transferred 1 blastocyst (31% vs 2,5%; p = 0,001 and 31,5% vs 2,8%; p = 0,001). Conclusion: The transfer of single good quality frozen blastocyst in patients under 35 years of age reduces the multiple pregnancy rate, while ensuring the same clinical and ongoing pregnancy and live birth rates as compared with double blastocyst transfer.
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Keywords
Single blastocyst transfer, frozen embryo transfer
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