NGHIÊN CỨU MỐI LIÊN QUAN GIỮA NỒNG ĐỘ ADIPONECTIN, LEPTIN HUYẾT THANH VỚI ĐÁI THÁO ĐƯỜNG THAI KỲ

Abstract

Background: Besides the gold-standard is the oral glucose tolerance test, in recent years, the identification of other biomarkers to predict, screening and diagnosis of gestational diabetes mellitus (GDM) are concerned. A crucial role in the pathogenesis of GDM seems to be also played by adipose tissue. Beyond its role of energy storage, adipocyte tissue represents an important endocrine organ that regulates many biological functions through the production of hormones, known as adipokines, such as adiponectin, leptin, TNFa and resistin…As such, adiponectin and leptin has been studied as potential biomarkers for GDM. Objectives: The aim of the study was to determine the relationship between serum adiponectin, leptin concentration with GDM. Materials and methods: A  case  - control study was  conducted  with  106  pregnant women  from  24  to  28  weeks  of  gestation  who  have  antenatal  care  at  Can Tho obstetrics and gynecology hospital, selected 51 pregnant  women  with  GDM  as  cases  and  55  pregnant women  without  GDM  as  controls  according  to diagnostic  criteria  of  the  American  Diabetes Association 2018.  Serum adiponectin, leptin concentration was measured using enzyme-linked immunosorbent assay (ELISA). Results: Serum adiponectin concentrations were statistically significant lower in the subjects with GDM than in healthy pregnant subjects (3,46 ±1,07 µg/ml vs. 5,52 ±2,76 µg/ml, p < 0.001). Serum leptin concentration was 8,69 ±6,80 ng/ml and 7,52 ±4,52 ng/ml in case and control groups, the differrence was not significantly (p=0,28). Conclusion: There was no association found between serum leptin concentration and GDM, but serum concentrations of adiponectin were significantly lower in gestational diabetic women and this may associate with an increased risk of GDM.