Article Sidebar

PDF
Date Published: 26/08/2022
Abstract Views: 309
Views PDF: 208
DOI: https://doi.org/10.51298/vmj.v517i2.3218
Issue
Vol. 517 No. 2 (2022)
Section
Các bài báo
How to Cite
Tấn Vinh, N. ., Hữu Dũng, N. ., & Việt Thắng, L. . (2022). RELATIONSHIP BETWEEN PLASMA C-REACTIVE PROTEIN CONCENTRATION WITH CAROTID ARTERIOSCLEROSIS AND PLASMA GLUCOSE CONTROL IN TYPE 2 DIABETIC MELLITUS PATIENTS. Vietnam Medical Journal, 517(2). https://doi.org/10.51298/vmj.v517i2.3218

RELATIONSHIP BETWEEN PLASMA C-REACTIVE PROTEIN CONCENTRATION WITH CAROTID ARTERIOSCLEROSIS AND PLASMA GLUCOSE CONTROL IN TYPE 2 DIABETIC MELLITUS PATIENTS

Nguyễn Tấn Vinh1, Nguyễn Hữu Dũng2,, Lê Việt Thắng3
1 Southern Binh Thuan Regional General Hospital
2 Bach Mai Hospital
3 Military Hospital 103, Vietnam Military Medical University

Main Article Content

Abstract

Objectives: Analysis of the relationship between plasma CRP levels and carotid atherosclerosis and blood glucose control in patients with type 2 diabetes. Subjects and methods: A cross-sectional study on 122 patients with type 2 diabetes. All patients had plasma CRP levels quantified by immunoassay turbidity, carotid Doppler ultrasound and situation of plasma glucose control according to the fasting blood glucose concentration. Results: There was a positive, moderate correlation between the CRP levels and the carotid intima-media thickness in patients with type 2 diabetes, r=0.622, p<0.001. The group of patients with carotid atherosclerosis had a 40.33 times higher risk of increasing plasma CRP levels than the non-atherosclerotic group, p<0.001. Patients with poor blood glucose control had a 2.13 times higher risk of CRP elevation compared with the group of patients with good and acceptable blood glucose control, p<0.05. Conclusion: Increased plasma CRP levels are associated with atherosclerosis and poor blood glucose control in patients with type 2 diabetes.

Article Details

Keywords

Type 2 diabetes, C-reactive protein, Atherosclerosis, Carotid Doppler ultrasound

References

1. Gu P, Kang D, Wang W, et al. (2013). Relevance of Plasma Obestatin and Early Arteriosclerosis in Patients with Type 2 Diabetes Mellitus. J Diabetes Res: 563919.
2. Tanaka K, Okada Y, Maiko H, et al. (2021). Associations between urinary 6‐sulfatoxymelatonin excretion and diabeticvascular complications or arteriosclerosis in patients with type 2 diabetes. J Diabetes Investig. 12(4): 601–609.
3. Shoelson SE, Lee J, Goldfine AB. (2006). Inflammation and insulin resistance. J Clin Invest. 116(7):1793-801.
4. Nguyen TPN, Luong CT, Tran TTH, et al. (2022). Lower Plasma Albumin, Higher White Blood Cell Count and High-Sensitivity C-Reactive Protein are Associated with Femoral Artery Intima-Media Thickness Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus. Int J Gen Med. 15: 2715–2725.
5. Eid S, Sas KM, Abcouwer SF, et al. (2019). New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism. Diabetologia. 62(9): 1539-1549.
6. Kanter JE, Bornfeldt KE. (2016). Impact of Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 36(6):1049-53.
7. Bùi Hữu Hoàng, Đào Bùi Quý Quyền, Lê Việt Thắng (2021). Khảo sát nồng độ hs-CRP huyết tương ở bệnh nhân đái tháo đường típ 2 có bệnh thận mạn. Tạp chí Y học Việt nam: số 2 (503): 28-31.
8. Lê Đình Tuân, Nguyễn Thị Hồ Lan (2017). Khảo sát đặc điểm biến chứng thận ở bệnh nhân Đái tháo đường typ 2 điều trị ngoại trú tại Bệnh viện nội tiết trung ương. Tạp chí Y Dược học quân sự. 55-62.