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Date Published: 26/08/2022
Abstract Views: 196
Views PDF: 366
DOI: https://doi.org/10.51298/vmj.v517i2.3238
Issue
Vol. 517 No. 2 (2022)
Section
Các bài báo
How to Cite
Minh Anh, P. ., & Trung Thọ, L. . (2022). RELATIONSHIP BETWEEN THE EXPRESSIONS OF PD-L1 AND SOME OF PATHOLOGICAL CHARACTERISTICS OF GASTRIC ADENOCARCINOMA. Vietnam Medical Journal, 517(2). https://doi.org/10.51298/vmj.v517i2.3238

RELATIONSHIP BETWEEN THE EXPRESSIONS OF PD-L1 AND SOME OF PATHOLOGICAL CHARACTERISTICS OF GASTRIC ADENOCARCINOMA

Phạm Minh Anh1,, Lê Trung Thọ1
1 Hanoi Medical University

Main Article Content

Abstract

Objectives: To evaluate the expression of PD-L1 and find its relationship with some histopathological features in GAC. Materials and methods: A cross-sectional study on 115 GAC patients confirmed by histopathology on surgical specimens and stained  monoclonal antibody PD-L1 by immunohistochemistry at the Pathology – Cytology Department of Hanoi Oncology Hospital from January 2015 to December 2019. Results: The prevalence of positive PD-L1 expression (CPS ≥1) in GAC was 37.4% (43/115 cases). There was no diffenrence in the prevelance of PD-L1 expression between  location and size of tumor; histopathological classification; differentiation and lymph node metastasis status. However, there was a statistically significant difference in the prevalence of PD-L1 expression between the invasive stage in GAC. Conclusion: The prevalence of positive PD-L1 expression in GAC was 37.4% (CPS ≥ 1). Tumors with higher invasive stage had a higher prevalence of PD-L1 expression than those with early stage.

Article Details

Keywords

PD-L1 expression, immunohistochemistry, gastric adenocarcinoma

References

1. Sundar R, Smyth EC, Peng S, Yeong JPS, Tan P. (2020). Predictive Biomarkers of Immune Checkpoint Inhibition in Gastroesophageal Cancers. Front Oncol. 10:763.
2. Nguyễn Mai Hạnh, Đặng Thái Trà, Trần Ngọc Dũng. (2021). Nhận xét mối liên quan giữa sự bộc lộ PD-L1, Her2/neu và mô bệnh học trong ung thư biểu mô tuyến dạ dày. Tạp chí Y dược học quân sự, 46 (9): 69-80.
3. Heo YJ, Kim B, Kim H, Kim S, Jang MS, Kim KM. (2021). PD-L1 expression in paired biopsies and surgical specimens in gastric adenocarcinoma: A digital image analysis study. Pathol Res Pract. 218:153338.
4. Hou J, Yu Z, Xiang R, et al. (2014). Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancer. Exp Mol Pathol. 96(3):284-291.
5. Wu C, Zhu Y, Jiang J, Zhao J, Zhang XG, Xu N. (2006). Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem. 108(1):19-24.
6. Wu Y, Cao D, Qu L, et al. (2017). PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer. Oncotarget. 8(38):64066-64082.
7. Eto S, Yoshikawa K, Nishi M, et al. (2016). Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection. Gastric Cancer. 19(2):466-471.
8. Geng Y, Wang H, Lu C, et al. (2015). Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance. Int J Clin Oncol. 20(2):273-281.
9. Mu L, Yu W, Su H, et al. (2019). Relationship between the expressions of PD-L1 and tumour-associated fibroblasts in gastric cancer. Artif Cells Nanomedicine Biotechnol. 47(1):1036-1042.