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Date Published: 26/08/2022
Abstract Views: 151
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DOI: https://doi.org/10.51298/vmj.v517i2.3238
Issue
Vol. 517 No. 2 (2022)
Section
Các bài báo
How to Cite
Minh Anh, P. ., & Trung Thọ, L. . (2022). RELATIONSHIP BETWEEN THE EXPRESSIONS OF PD-L1 AND SOME OF PATHOLOGICAL CHARACTERISTICS OF GASTRIC ADENOCARCINOMA. Vietnam Medical Journal, 517(2). https://doi.org/10.51298/vmj.v517i2.3238

RELATIONSHIP BETWEEN THE EXPRESSIONS OF PD-L1 AND SOME OF PATHOLOGICAL CHARACTERISTICS OF GASTRIC ADENOCARCINOMA

Phạm Minh Anh1,, Lê Trung Thọ1
1 Hanoi Medical University

Main Article Content

Abstract

Objectives: To evaluate the expression of PD-L1 and find its relationship with some histopathological features in GAC. Materials and methods: A cross-sectional study on 115 GAC patients confirmed by histopathology on surgical specimens and stained  monoclonal antibody PD-L1 by immunohistochemistry at the Pathology – Cytology Department of Hanoi Oncology Hospital from January 2015 to December 2019. Results: The prevalence of positive PD-L1 expression (CPS ≥1) in GAC was 37.4% (43/115 cases). There was no diffenrence in the prevelance of PD-L1 expression between  location and size of tumor; histopathological classification; differentiation and lymph node metastasis status. However, there was a statistically significant difference in the prevalence of PD-L1 expression between the invasive stage in GAC. Conclusion: The prevalence of positive PD-L1 expression in GAC was 37.4% (CPS ≥ 1). Tumors with higher invasive stage had a higher prevalence of PD-L1 expression than those with early stage.

Article Details

Keywords

PD-L1 expression, immunohistochemistry, gastric adenocarcinoma

References

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