U CASTLEMAN TRONG TRUNG THẤT SAU – TỔNG QUAN TÀI LIỆU VÀ BÁO CÁO CA BỆNH

Abstract

Castleman Disease (CD) is a rare lymphoproliferative disorder typically characterized by the proliferation of a single or regional lymph node, usually occurring in the chest. Patients with CD may be asymptomatic or present with symptoms related to tumor impact on surrounding structures. It is difficult to reach a definitive diagnosis by imaging alone. Computed tomography and/or magnetic resonance imaging play a dominant role in supporting the diagnosis. Histological examination of lesions combined with immunohistochemical staining is the gold standard for disease identification. Complete surgical resection is the best primary treatment modality for CD, offering long-term survival and low recurrence rates. A few can be combined with monoclonal antibody therapy to be effective. In the chest, Castleman tumors are usually found in the anterior mediastinum and very rarely in the posterior mediastinum. We report one case of CD found in the posterior mediastinum, twice transthoracic biopsies gave incorrect results. The patient underwent surgery, histopathological results  and immunohistochemical staining confirmed a CD tumor. The discussion of the literature review will help readers gain a deeper understanding of this disease.