ĐẶC ĐIỂM TRIỆU CHỨNG LÂM SÀNG VÀ CẬN LÂM SÀNG BỆNH NHÂN UNG THƯ PHỔI BIỂU MÔ VẢY GIAI ĐOẠN MUỘN TẠI BỆNH VIỆN K

Abstract

Objective: Describing the clinical and subclinical symptoms of patients diagnosed of advanced/ metastatic squamous cell lung cancer at National Cancer Hospital from 01/2017 to 05/2022. Patients and method: Retrospective and prospective analysis of 65 patients with advanced/ metastatic squamous cell lung carcinoma were diagnosed and treated at National Cancer Hospital from 01/2017 to 05/2022. Results: The average age was 56.9±1.2, rate of male patients was 80%. Most of patients related to history of smoking (accounted for 93.8%) and medical history of chronic obstructive pulmonary disease (accounted for 78.5%). The common symptoms of advanced lung cancer patients were dry cough, chest pain and hemoptysis, accounting for 83.1%; 76.9% and 69.2%, respectively. For performance status, ECOG 1 accounted for 58.5%. Most of patients were stages T4 and N3, accounting for 53.8% and 44.6%, respectively. The common metastatic locations in our patients were bone, lung and pleural/pericardial metastases, accounting for 67.7%; 64,6% and 58.5%, respectively. In our study, there were 44 patients analyzed PD-L1 expressions and rates of patients with PD-L1 expressions < 1%; 1-49% and ³ 50% were 34.1%; 36.4% and 29.5%, respectively. Conclusion: Advanced/metastatic squamous cell lung cancer often occured in middle-older age male patients and history of smoking. The common symptoms were dry cough, chest pain and hemoptysis with presence of bone and lung metastases.