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Date Published: 26/08/2022
Abstract Views: 257
Views PDF: 167
DOI: https://doi.org/10.51298/vmj.v517i2.3286
Issue
Vol. 517 No. 2 (2022)
Section
Các bài báo
How to Cite
Thị Ánh Tuyết, P. ., Đức Bình, V. ., Lan Phương, N. ., Thị Minh Nguyệt, N., Thị Thu Thủy, N. ., Thành Đạt, T. ., Văn Hưng, L. ., & Hoàng Việt, N. . (2022). IDENTIFICATION OF SINGLE NUCLEOTIDE POLYMORPHISM rs2596542 OF MICA GENE ON LYMPHOMA PATIENTS BY REALTIME PCR. Vietnam Medical Journal, 517(2). https://doi.org/10.51298/vmj.v517i2.3286

IDENTIFICATION OF SINGLE NUCLEOTIDE POLYMORPHISM rs2596542 OF MICA GENE ON LYMPHOMA PATIENTS BY REALTIME PCR

Phạm Thị Ánh Tuyết1, Vũ Đức Bình2, Nguyễn Lan Phương2, Nguyễn Thị Minh Nguyệt2, Ngô Thị Thu Thủy3, Tạ Thành Đạt3, Lê Văn Hưng3, Nguyễn Hoàng Việt3,
1 Tuyen Quang Provincial General Hospital
2 National Institute of Hematology and Blood Transfusion
3 Department of Medical Technology, Hanoi Medical University

Main Article Content

Abstract

Background: The MICA gene encodes for MICA molecule, acts as ligands for the immunogenic NKG2D receptor. The expression of MICA can be caused by inducing “stress” in cells that are malignantly transformed or infected with viruses. Several studies have investigated the relationship between SNP rs2596542 on MICA gene and the risk of nasopharyngeal cancer, hepatocellular carcinoma caused by hepatitis C virus and hepatitis B virus. However, no studies have been performed on patients with lymphoma. Objectives: Identification of SNP rs2596542 on MICA gene and the risk of lymphoma. Materials and methods: This study determined the allele frequency of SNP rs2596542C/T on MICA gene in lymphoma patients was 29.5% T, 70.5% C, respectively; genotype distribution is 53% CC, 35% CT and 12% TT, respectively. However, no statistical significance was observed between genotype and allele frequency of SNP rs2596542 in the patient and control group.

Article Details

Keywords

lymphoma, MICA gene, rs2596542

References

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