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Date Published: 26/08/2022
Abstract Views: 595
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DOI: https://doi.org/10.51298/vmj.v517i2.3291
Issue
Vol. 517 No. 2 (2022)
Section
Các bài báo
How to Cite
Thị Thanh Hoa, P., Quang Trung, N. ., & Mạnh Phương, H. . (2022). RESULT EVALUATION OF LONG-TERM LOW-DOSE MACROLIDE ANTIBIOTIC TREATMENT IN CHRONIC RHINOSINUSITIS WITH POLYP AFTER ENDOSCOPIC SINUS SURGERY. Vietnam Medical Journal, 517(2). https://doi.org/10.51298/vmj.v517i2.3291

RESULT EVALUATION OF LONG-TERM LOW-DOSE MACROLIDE ANTIBIOTIC TREATMENT IN CHRONIC RHINOSINUSITIS WITH POLYP AFTER ENDOSCOPIC SINUS SURGERY

Phan Thị Thanh Hoa1,, Nguyễn Quang Trung2, Hồ Mạnh Phương3
1 Military Hospital 354
2 Hanoi Medical University
3 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Objective: Result evaluation of long- term low- dose Macrolide therapy in patients with chronic rhinosinusitis with polyps after endoscopic sinus surgery. Methods: Opinion overview, we used data from Pubmed, Cochrane and Embase to evaluate the results of long-term low-dose Macrolide therapy in reducing polyp recurrence in patients with chronic rhinosinusitis with polyp after endoscopic sinus surgery. Results: There are 7 studies, in which 5 are randomized controlled trials and 2 are prospective studies with pre and post – treatment comparisons with 448 patients in this review, of recent 10 years duration. The antibiotics used in the studies are Clarythromycin and Azithromycin, half- dose and lasting 4 to 24 weeks; There are 6 studies showed improvement in the SNOT 20/22 scale with p< 0.05; 5 studies found an improvement in the endoscopy scale of Lun – Kenedy with p < 0.05; only two studies evaluated by CT Lund- Mackay scale showed improvement with p< 0.05; four studies evaluating tissue eosinophil presence, serum IgE, and Nasal secretion found whether macrolide therapy is effective in the patients with low IgE. Conclusion: the results of long-term low-dose macrolide therapy in patients with chronic rhinosinusitis with polyps after endoscopic sinus surgery improved quality of life as well as reduced polyp recurrence, especially in patients with low IgE.

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References

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