Article Sidebar

PDF
Date Published: 26/08/2022
Abstract Views: 725
Views PDF: 358
DOI: https://doi.org/10.51298/vmj.v517i2.3291
Issue
Vol. 517 No. 2 (2022)
Section
Các bài báo
How to Cite
Thị Thanh Hoa, P., Quang Trung, N. ., & Mạnh Phương, H. . (2022). RESULT EVALUATION OF LONG-TERM LOW-DOSE MACROLIDE ANTIBIOTIC TREATMENT IN CHRONIC RHINOSINUSITIS WITH POLYP AFTER ENDOSCOPIC SINUS SURGERY. Vietnam Medical Journal, 517(2). https://doi.org/10.51298/vmj.v517i2.3291

RESULT EVALUATION OF LONG-TERM LOW-DOSE MACROLIDE ANTIBIOTIC TREATMENT IN CHRONIC RHINOSINUSITIS WITH POLYP AFTER ENDOSCOPIC SINUS SURGERY

Phan Thị Thanh Hoa1,, Nguyễn Quang Trung2, Hồ Mạnh Phương3
1 Military Hospital 354
2 Hanoi Medical University
3 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Objective: Result evaluation of long- term low- dose Macrolide therapy in patients with chronic rhinosinusitis with polyps after endoscopic sinus surgery. Methods: Opinion overview, we used data from Pubmed, Cochrane and Embase to evaluate the results of long-term low-dose Macrolide therapy in reducing polyp recurrence in patients with chronic rhinosinusitis with polyp after endoscopic sinus surgery. Results: There are 7 studies, in which 5 are randomized controlled trials and 2 are prospective studies with pre and post – treatment comparisons with 448 patients in this review, of recent 10 years duration. The antibiotics used in the studies are Clarythromycin and Azithromycin, half- dose and lasting 4 to 24 weeks; There are 6 studies showed improvement in the SNOT 20/22 scale with p< 0.05; 5 studies found an improvement in the endoscopy scale of Lun – Kenedy with p < 0.05; only two studies evaluated by CT Lund- Mackay scale showed improvement with p< 0.05; four studies evaluating tissue eosinophil presence, serum IgE, and Nasal secretion found whether macrolide therapy is effective in the patients with low IgE. Conclusion: the results of long-term low-dose macrolide therapy in patients with chronic rhinosinusitis with polyps after endoscopic sinus surgery improved quality of life as well as reduced polyp recurrence, especially in patients with low IgE.

Article Details

References

1. Bezerra TFP, Pezato R, de Barros PM, et al. Prospective evaluation of clarithromycin in recurrent chronic rhinosinusitis with nasal polyps. Braz J Otorhinolaryngol. 2021;87(3):298-304
2. Lin CF, Wang MC, Merton AT, et al. Add-on effect of clarithromycin to oral steroids as post- operative therapy for chronic rhinosinusitis with nasal polyps: a randomised controlled trial. Rhinology. 2020;58(6):550-558.
3. Maniakas A, Asmar MH, Renteria AE, et al. Azithromycin in high-risk, refractory chronic rhinosinusitus after endoscopic sinus surgery and corticosteroid irrigations: a double-blind, randomized, placebo-controlled trial. Int Forum Allergy Rhinol. 2021;11(4):747-754.
4. Perot B, Baban M. The Role of the Macrolide in Preventing Recurrence of the Nasal Polyposis after Fess. Pak J Med Health Sci. 2021;14.
5. Sireci F, Speciale R, Gallina S, Sorrentino R, Canevari FR. Clarithromycin in the Management of Chronic Rhinosinusitis: Preliminary Results of a Possible Its New Use. Indian J Otolaryngol Head Neck Surg Off Publ Assoc Otolaryngol India. 2018;70(1):87-91
6. Varvyanskaya A, Lopatin A. Efficacy of long-term low-dose macrolide therapy in preventing early recurrence of nasal polyps after endoscopic sinus surgery. Int Forum Allergy Rhinol. 2014;4(7):533-541.
7. Zeng M, Wang H, Liao B, et al. Comparison of efficacy of fluticasone propionate versus clarithromycin for postoperative treatment of different phenotypic chronic rhinosinusitis: a randomized controlled trial. Rhinology. 2019;57(2):101-109.