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ANTIMICROBIAL RESISTANT STATUS OF KLEBSIELLA PNEUMONIAE ISOLATED FROM PATIENT SPECIMENS AT CAN THO CITY GENERAL HOSPITAL AND CAN THO CENTRAL GENERAL HOSPITAL IN 2021-2022
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Abstract
Background: Today, antibiotic resistance of bacteria is a top problem of the health industry in our country as well as in many countries around the world. In there, Klebsiella pneumoniae is a common cause of bacterial infections with high levels of antibiotic resistance. Objectives: Analyzing the antibiotic resistance of Klebsiella pneumoniae isolated from patient samples Materials and methods: 345 strains of Klebsiella pneumoniae were isolated, identified, made antibiotic by MIC method on the automated identification and susceptibility testing system. The resistant antibiotic test results made according to MIC of the CLSI 2020. Results: Most of Klebsiella pneumoniae was resistant to various antibiotics: ampicillin 99.4%, cephalosporins 61.2% to 76.5%, piperacilin/tazobactam 52.2%, ciprofloxacin 69.9%, trimethoprim/sulfamethoxazole 55.4%, carbapenems 43.2% to 49.0 %. The lowest rate of resistance was amikacin 17.4%. However, the remaining antibiotic in the aminoglycoside group was gentamicin, which had an average resistance rate with 40.6%. The overall proportion of multidrug resistance Klebsiella pneumoniae isolates in this study was 75.7%. Conclusion: Most of the Klebsiella pneumoniae isolates showed resistance to a wide range of antibiotics with high rate of multidrug resistance.
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Keywords
Antibiotic Resistance, Klebsiella pneumoniae, multidrug resistance
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