TÍNH KHÁNG KHÁNG SINH CỦA VI KHUẨN HAEMOPHILUS INFLUENZE VÀ KẾT QUẢ ĐIỀU TRỊ VIÊM PHỔI DO HAEMOPHILUS INFLUENZE Ở TRẺ EM TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Backgroud: H.influenzae is one of the main pathogens that cause community- acquired pneumonia in children. The aim of our study was to estimate the prevalence of H.influenzae antibiotic resistance and the results of treatment among patients suffering from pneumonia caused by H.influenzae in Vietnam National Children’s Hospital. Methods: The study included 151 children with pneumonia caused by H.influenzae from 1 month to 15 years old treated at the Respiratory Center - Viet Nam National Children's Hospital from January 2020 to December 2021. Results: The antibiotic resistance rate of H.influenzae was very high with ampicillin 92.1%; Amoxicillin 92.7%; Cefaclor 84.4%; Cefuroxime 80.1%; Co-trimoxazole 94.7%; reduced sensitivity to Amoxicillin/A.Clavunanic (603%); and not susceptible with Cefixime 71.9%; Azithromycin 54.4%. However, H.influenzae is still susceptible to Ceftriaxone (98.7%); Ciproflozaxin (95.4%) and Meropenem (100%). Treatment results: 7.9% of patients were fully recovered from the disease, and 92.1% of patients were not fully recovered and no patients progressed to severe disease or died. The mean of hospitalization was 7.1 ± 4.4 days. Conclusions: H.influenzae has a very high rate of resistance to commonly used antibiotics to treatmen of pneumonia. Inappropriate use of antibiotics and overuse of antibiotics increase the rate of antibiotic resistance of H.influenzae bacteria in particular and pathogenic bacteria in general. H.influenzae is also highly susceptible to Ceftriaxone and Meropenem. The treatment results were good, there was no patient worsening and no patient died. Keywwords: Haemophilus influenzae, pneumonia, children, antibiotic resistance.