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Date Published: 23/09/2022
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DOI: https://doi.org/10.51298/vmj.v518i1.3313
Issue
Vol. 518 No. 1 (2022)
Section
Các bài báo
How to Cite
Thị Hoa, N. ., Thị Huyền, P. ., Thị Yến, L. ., Thị Hòa, N. ., & Thị Hồng Nhật, Đoàn . (2022). RESULTS OF ADJUVANT CHEMOTHERAPY DOCETAXEL - CARBOPLATIN – TRASTUZUMAB REGIMEN IN HER2/NEU POSITIVE BREAST CANCER PATIENTS. Vietnam Medical Journal, 518(1). https://doi.org/10.51298/vmj.v518i1.3313

RESULTS OF ADJUVANT CHEMOTHERAPY DOCETAXEL - CARBOPLATIN – TRASTUZUMAB REGIMEN IN HER2/NEU POSITIVE BREAST CANCER PATIENTS

Nguyễn Thị Hoa1,, Phùng Thị Huyền2, Lê Thị Yến2, Nguyễn Thị Hòa2, Đoàn Thị Hồng Nhật3
1 Hung Vuong General Hospital, Phu Tho Province
2 Vietnam National Cancer Hospital
3 Vinh Medical University

Main Article Content

Abstract

Objectives: To evaluate the efficacy of adjuvant chemotherapy Docetaxel – Carboplatin – Trastuzumab regimen in Her2/neu positive breast cancer patients. Subjects and methods: A descriptive cohort study was conducted on 51 patients with stage I – II – IIIA breast cancer (BC) after radical mastectomy or conservative surgery with systemic axillary lymph node dissection received adjuvant chemotherapy Docetaxel – Carboplatin – Trastuzumab regimen at K hospital from January 2014 to the end of May 2021, and followed up until the end of May 2022. Results: The most common age group in our study is 60 – 70 years old, accounting for 49.0%; 45.1% of patients had stage I. The majority of patients received modified radical mastectomy, accounting for 90.2%. Patients with adjuvant radiation therapy accounted for 43.1%; 23.5% of patients received adjuvant AI treatment. Adjuvant Tamoxifen accounted was administered in 15.7% patients. Median disease free survival was 71.0 (95%CI: 60.7 – 81.3) months. The rate of neutropenia is 43.1%; in which grade 3 – 4 neutropenia accounted for 17.6%; the rate of neutropenia with fever is 11.8%; There were no cases of anemia or thrombocytopenia grade 3 – 4; The rate of EF reduction > 16% was 0.5%. Conclusion: Adjuvant chemotherapy Docetaxel – Carboplatin – Trastuzumab regimen has good efficacy in prolonging disease free survival time as well as low toxicity for breast cancer patients.

Article Details

Keywords

BC (breast cancer)

References

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