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INVESTIGATION OF BLOOD HOMOCYSTEINE CONCENTRATION TYPE II DIABETES WITH HYPERTENSION
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Abstract
Background: Preventing hypertension in patients with type 2 diabetes is essential which helps to reduce cardiovascular complications. Homocysteine is known as an independent risk factor for cardiovascular diseases. Increased homocysteine concentration in the blood leads to metabolic disorders, damaged endothelial cells, dysfunction of vascular walls, and hypertension. Aims: This study aims to investigate the blood homocysteine concentration and analyze the correlation with blood pressure in patients with type 2 diabetes, then determine the diagnostic value of blood homocysteine concentration in predicting hypertension in patients with type 2 diabetes. Objective and methods: A cross-sectional study and analytic was performed on 175 type 2 diabetes patients in the outpatient department at the Endocrine Clinic - Cho Ray Hospital from January 2022 to June 2022, and was divided into 2 groups: type 2 diabetes with hypertension including 86 patients and type 2 diabetes without hypertension included 89 patients. Results: The median value of homocysteine in type 2 diabetes with hypertension (13.3 µmol/l) was higher than in subjects without hypertension. Besides, the increased concentration of homocysteine were observed in the high level of blood pressure: non-hypertension, isolated systolic hypertension, grade 1 hypertension, grade 2 hypertension, grade 3 hypertension (9.7µmol/l, 10.3µmol/l, 13.3µmol/l, 16.5µmol/l, and 18.96 µmol/l, respectively). Moreover, a moderate correlation between homocysteine concentration and systolic blood pressure (r=0.467, p<0.001) and diastolic blood pressure (r=0.473, p<0.001) was observed. Notably, the blood homocysteine concentration may serve as a diagnostic marker for hypertension in type 2 diabetes with a cut-off point of 10.68µmol/L, 73.3% sensitivity, 62.9% specificity, and AUC value of 0.74 (95%CI: 0.67 – 0.81). Conclusion: The blood homocysteine concentration in type 2 diabetes with hypertension was higher than those without hypertension and correlated with blood pressure. Besides, the blood homocysteine concentration may serve as a diagnostic marker for hypertension in patients with type 2 diabetes.
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Keywords
homocysteine, diabetes with hypertension
References
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