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Date Published: 23/09/2022
Abstract Views: 155
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DOI: https://doi.org/10.51298/vmj.v518i1.3359
Issue
Vol. 518 No. 1 (2022)
Section
Các bài báo
How to Cite
Thị Thúy, L. ., Thành Văn, T. ., Thị Ngọc Lan, V. ., Anh Khoa, T. ., Thị Lệ Hằng, T. ., Khánh Hải, P. ., & Trung Thế, L. . (2022). SINGLE NUCLEOTID 45T/G ADIPONECTIN GENE IN GESTATIONAL DIABETES MELLITUS PATIENTS. Vietnam Medical Journal, 518(1). https://doi.org/10.51298/vmj.v518i1.3359

SINGLE NUCLEOTID 45T/G ADIPONECTIN GENE IN GESTATIONAL DIABETES MELLITUS PATIENTS

Lê Thị Thúy1, Tạ Thành Văn2, Vũ Thị Ngọc Lan1,, Trần Anh Khoa1, Trần Thị Lệ Hằng3, Phan Khánh Hải4, Lê Trung Thế4
1 Danang University of Medical Technology and Pharmacy
2 Hanoi Medical University
3 Danang Obstetrics and Pediatrics Hospital
4 Danang Hospital

Main Article Content

Abstract

Objective: We investigated the relationship between the single nucleotid polymorphism 45T/G in the adiponectin gene and risk of gestational diabetes mellitus (GDM) in Vietnamese population. Subjects and method: 45 GDM patients and 45 healthy pregnant women were enrolled in our study. Genotyping for SNP 45T/G in the adiponectin gene was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Result: The G allele and TG/GG genotype of SNP 45T/G adiponectin gene were more frequent than the T allele and TT genotype in GDM patient compared to the controls (p<0,05). After statistical adjustment for age and body mass index prepregnant, the SNP 45T/G adiponectin gene was found to be associated with increased risk of GDM under multiple inheritance models: codominant (OR=6,99; 95%CI=1.47 – 33,17), dominant (OR=3,14; 95%CI=1.20 – 8,18) and recessive (OR=4,35; 95%CI=1,02–18,62). Conclusion: SNP 45T/G in the adiponectin gene is associated with risk of developing GDM in Vietnamese population.

Article Details

Keywords

SNP 45T/G, adiponectin gene, gestational diabetes mellitus

References

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