MỐI LIÊN QUAN GIỮA TỔN THƯƠNG PHỔI VÀ MỘT SỐ TỰ KHÁNG THỂ TRONG BỆNH XƠ CỨNG BÌ

Abstract

Objective: To investigate the association between lung injury and some autoantibodies in scleroderma. Subjects of the study: 65 patients diagnosed with scleroderma according to ACR/ EULAR 2013 standards and treated at the Respiratory center, Rheumatology department in Bach Mai hospital and in National hospital of Dermatology and Venereology. Methods: Prospective, cross-sectional study. Results and conclusion: 73.8% of patients participating in the study had lung damage, of which ILD alone accounted for the highest percentage (35.4%), ILD combined with PAH accounted for 26.2%, PAH alone 6.2%, ILD in collaboration with PE accounted for 3.1%. Interstitial lung disease is mainly seen in generalized scleroderma, there is no difference in the rates of PAH and PE between scleroderma types. Scl70 autoantibodies are common in generalized scleroderma, anti-Centromere antibodies are common in focal scleroderma. There is an association between ILD and anti-Scl70 antibodies, PAH and anti-Centromere antibodies.