COMPARISON OF CLINICAL AND PARACLINICAL CHARACTERISTICS IN AFB-POSITIVE AND NEGATIVE NEWLY PULMONARY TUBERCULOSIS PATIENTS AT MILITARY HOSPITAL 103

Tạ Bá Thắng1, Nguyễn Công Hoàng Anh1, Trần Thị Nhung1, Đào Ngọc Bằng1,
1 Military Hospital 103

Main Article Content

Abstract

Objective: To compare clinical and paraclinical characteristics in AFB-positive and negative newly tuberculosis patients with at Military Hospital 103. Subjects and methods: A prospective, cross-sectional study on 42 AFB-positive and negative newly pulmonary tuberculosis (TB) patients, treated at Military Hospital 103 from December 2021 to Jun 2022. Results: The average age of AFB-positive pulmonary TB patients was 51.32  ± 20.13 years old, lower than that in the AFB-negative group, with the average one of 63.12 ± 15.51 (p<0.05). Lesions on chest X-ray image were mainly in the upper lobe, with the most common being infiltrative, bilateral ones in both groups. Cavitary lesion was seen more statistically in the AFB-positive group than in the AFB-negative one. 4.76% of patients had resistance to first-line anti-TB drugs. Conclusions: Pulmonary TB patients with AFB-positive were younger and had more subjective symptoms and infiltrative, cavitary lesions on chest X-ray image in comparison with TB ones with AFB-negative.

Article Details

References

1. World Health Organization. Global tuberculosis control: WHO report 2021.
2. Bộ Y tế (2020), “Hướng dẫn chẩn đoán, điều trị và dự phòng lao”.
3. Ahmad N., Baharom M., Aizuddin A.N., et al. (2021). Sex-related differences in smear-positive pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: Prevalence and associated factors. PLoS One.;16(1):e0245304.
4. Wang Y., Shang X., Wang L., et al. (2021). Clinical characteristics and chest computed tomography findings related to the infectivity of pulmonary tuberculosis. BMC Infect Dis.;21(1):1197.
5. Kang W., Du J., Yang S., et al. (2021). The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study. Eur J Clin Microbiol Infect Dis 40, 787–800 (2021).
6. Zhang Z.X., Sng L.H., Yong Y., et al. (2017) Delays in diagnosis and treatment of pulmonary tuberculosis in AFB smear-negative patients with pneumonia. Int J Tuberc Lung Dis.;21(5):544-549.
7. Qi M., Li P.J., Wang Y., et al. (2021). Clinical features of atypical tuberculosis mimicking bacterial pneumonia. Open Med;16(1):1608-1615.
8. Võ Trọng Thành (2019). Nghiên cứu sự thay đổi một số chỉ số huyết học ở bệnh nhân lao phổi được điều trị tại Bệnh viện Phổi Trung ương. Luận án Tiến sĩ Y học, Đại học Y Hà Nội, Hà Nội .
9. Rai D.K., Kirti R., Kumar S., et al. (2019). Radiological difference between new sputum-positive and sputum-negative pulmonary tuberculosis. J Family Med Prim Care.;8(9):2810-2813.
10. Ko J.M., Park H.J., Kim C. H., et al. (2015). The relation between CT findings and sputum microbiology studies in active pulmonary tuberculosis. European Journal of Radiology, 84(11), 2339–2344.