KẾT QUẢ ĐIỀU TRỊ BỆNH NHÂN UNG THƯ VÚ BỘ BA ÂM TÍNH GIAI ĐOẠN I-III TẠI BỆNH VIỆN UNG BƯỚU NGHỆ AN

Abstract

Overview: Breast cancer which is characterized by the lack of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (Triple negative - TN) accounts for 15% of all breast cancer, different from clinical symptoms, pathology, metastasis, recurrence. This subtype of breast cancer has worsen prediction associated recurrence time and overall survival. The purpose of this article is to evaluate out come of TN breast cancer treatment in Nghe An oncology hospital from 2015 to 2021. Patients and method: A retrospective study of 70 patients with stage I-III triple negative breast cancer (AJCC 2017) who was treated by surgery, AC-T chemotherrapy, radiation, had all characterizes to analysis of clinical, pathology, overall survival and relatives factors. Results: Average age: 51.04±9.66; min age: 20; max age: 72. The most common age is 51-60 ( 41.7%). Tumor with stage T2 accounts for 70% while stage T1 tumor is 20%. Lymph nodes metastasis rate involve in 48.3% of case. Most of patients with stage II-III occupy 81.4%. Most type of pathology is invasive ductal carcinoma (80%). Grade II and III is 90%. Only 2 patients was performed breast conserving surgery (2.8%); mastectomy surgery (97.2%). Adjuvant chemotherapy is 84.3%; neoadjuvant chemotherapy is 15.7%; radiation therapy is 62.9%. Disease free survival is 77.96 months on average. Disease free survival rate at 2,3,4,5 year are respectively 94%, 87.6%, 78.9%, 78.9%. Overall survival is 84.63 months on average. Overall survival rate at 2,3,4,5 year are respectively 98.6%, 98.6%, 94.3%, 87.6%. Lung and brain which are organs were metastasized the most with 36.4%, 27.2%, respectively. Difference between overall survival and axillary lymph node status (p= 0,01 and p= 0,002), overall survival and disease stage (p= 0,043) is significantly statistical.