MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG VIÊM NÃO TỰ MIỄN DO KHÁNG THỂ KHÁNG THỤ THỂ N-METHYL-D-ASPARTATE

Abstract

Objective: Determine the clinical characteristics Anti-NMDA receptor encephalitis.  Subjects: We selected 36 patients  were diagnosed Anti-NMDA receptor encephalitis at Bach Mai Hospital during January 2019 to October 2022. Methods: Cross-sectional descriptive study. Results: Thirty-six patients with anti-NMDAR encephalitis were enrolled (age from 14 years to 64 years old) median age: 30.7 ± 13.7 years, with a female predominance (63.9%). Patients admitted to the hospital with the most common reason was mental disorder (50%). Nineteen patients had onset of psychiatric symptoms (52.8%). In the group of psychiatric symptoms, twenty-two patients (61.1%) with bizarre behavior and disorganized thinking, in addition, delusion, cognitive disorders, progressive speech deterioration of language were also reported, often appear with the corresponding rate of 58.3%, 55.6%, 58.3%. In the group of neurological symptoms, Thirty patients (83.3%) with a decreased level of consciousness, 21 (58.3%) with seizures, 21 (58.3%) with sleep disturbances and 8 (22.2%) with autonomic instability. Conclusion: In summary, in the study of clinical features of NMDA encephalitis, we found that NMDA encephalitis is a common autoimmune encephalitis in young women, with the onset and predominant clinical symptoms being psychiatric disorders. This makes early diagnosis very difficult and delays treatment for patients.