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Date Published: 09/10/2022
Abstract Views: 440
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DOI: https://doi.org/10.51298/vmj.v518i2.3443
Issue
Vol. 518 No. 2 (2022)
Section
Các bài báo
How to Cite
Minh Ngọc, V. ., Văn Quân, L. ., Việt Hùng, Đinh ., Văn Trân, P. ., Thị Mai Ly, N. ., Ngọc Thảo, P. ., & Xuân Khái, N. . (2022). INVESTIGATION ON ANTIOXIDANT EFFECTS OF THE GREEN COFFEE BEAN EXTRACT IN EXPERIMENTAL ANIMALS. Vietnam Medical Journal, 518(2). https://doi.org/10.51298/vmj.v518i2.3443

INVESTIGATION ON ANTIOXIDANT EFFECTS OF THE GREEN COFFEE BEAN EXTRACT IN EXPERIMENTAL ANIMALS

Vũ Minh Ngọc1, Lê Văn Quân2,, Đinh Việt Hùng2, Phạm Văn Trân2, Nguyễn Thị Mai Ly2, Phạm Ngọc Thảo2, Nguyễn Xuân Khái2
1 Institute 69, The President Ho Chi Minh's Mausoleum Protecting Command
2 Military Hospital 103

Main Article Content

Abstract

Objectives: To investigate antioxidant effects of the green coffee bean extract (GCBE) in mice. Methods: 60 mice were injected by D-galactose in 4 weeks to induced oxidative stress. After then, they were treated by saline, GCBE at doses 200mg/kg, 300mg/kg and 400mg/kg or vitamin E for next 4 weeks. Liver concentrations of MDA (Malondialdehyde), SOD (Superoxide dismutase) and GSH-Px (Glutathione peroxidase) were measured. Results: Liver concentrations of GSH-Px in mice treated by GCBE at doses 300mg/kg and 400mg/kg were significantly higher than these in the control group (p<0,05). There were no significant differences in liver concentrations of MDA and SOD between groups (p>0,05). Conclusion: The present study presented new evidence of antioxidant effects of GCBE at doses 300mg/kg and 400mg/kg in mice.

Article Details

Keywords

Antioxidant, GCBE, mice

References

1. J. F. Turrens, “Mitochondrial formation of reactive oxygen species,” J. Physiol., 2003; 552(2): 335–344.
2. L. A. Pham-Huy, H. He, and C. Pham-Huy, “Free Radicals, Antioxidants in Disease and Health,” Int. J. Biomed. Sci. IJBS. 2008; 4(2): 89–96.
3. E. Dybkowska, A. Sadowska, R. Rakowska, M. Dębowska, F. Świderski, and K. Świąder, “Assessing polyphenols content and antioxidant activity in coffee beans according to origin and the degree of roasting.,” Rocz. Państw. Zakładu Hig. 2017; 68(4): 347–353.
4. Zhen YZ, Lin YJ, Li KJ, et al., Effects of rhein lysinate on D-galactose-induced aging mice. Exp Ther Med. 2016; 11(1): 303-308.
5. O. D. AlAmri et al., “Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fat-diet/streptozotocin-induced diabetes in male albino rats,” J. Funct. Foods. 2020; 71: 103996.
6. W. A. AL-Megrin et al., “Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats,” J. Diabetes Res. 2020; 2020: e6762709.
7. Q. A. Nogaim et al., “Protective effect of Yemeni green coffee powder against the oxidative stress induced by Ochratoxin A,” Toxicol. Rep. 2020; 7: 142–148.