NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG NHIỄM KHUẨN HUYẾT DO STAPHYLOCOCCUS AUREUS Ở NGƯỜI BỆNH CAO TUỔI

Abstract

Objectives: To study the clinical, subclinical characteristics and antibiotic resistance of bacteria in the elderly patients with bacteremia caused by S. aureus. Subjects and methods: A retrospective descriptive cross-sectional study on the records of patients diagnosed with bacteremia caused by S. aureus at Friendship Hospitals and 103 Military Hospitals from January 2018 to June 2022. Results and Conclution: There were 67 eligible patients included in the study and the results were as follows: Average age 77.39 ± 9.66; The male/female ratio was 5/1. There were 98.5% of patients with underlying diseases, in which hypertension (61.2%), sequelae of cerebrovascular accident (35.8%), diabetes (34.3%) were common. Nosocomial sepsis accounted for 70.1%. The entry routes from skin and mucous membranes were common (25.4%). 100% of patients had fever, of which 44.8% had chills. 46.5% of patients have consciousness disorder. 7.5% drop in blood pressure; 24.5% of patients had pleural effusion. 29.9% had signs of septic shock. The mortality rate was 25.4%; 66.7% of patients had anemia, 86.7% had coagulopathy. 57.1% of patients had leukocytosis; 98.5% had increasing CRP and 100% of patients had increasing PCT. The rate of Methicillin-resistant S.aureus (MRSA) was 65.6%; S.aureus was resistant to most of the Macrolide and Penicillin group antibiotics but was still 100% sensitive to Vancomycin. The average MIC of Vancomycin was 1.130±0.087. Other highly sensitive antibiotics were Tigecyclin, Linezolin, Amikacin.