Article Sidebar

PDF
Date Published: 09/10/2022
Abstract Views: 199
Views PDF: 139
DOI: https://doi.org/10.51298/vmj.v518i2.3458
Issue
Vol. 518 No. 2 (2022)
Section
Các bài báo
How to Cite
Đoàn Thuỷ, N. ., Văn Liệu, N. ., Thị Vân Anh, N. ., & Văn Sơn, C. (2022). CARBAMAZEPINE ALLERGY AND ITS ASSOCIATION WITH THE PRESENCE OF HLA-B*15:02 AND HLA-A*31:01 ALLELES IN TAM ANH HOSPITAL. Vietnam Medical Journal, 518(2). https://doi.org/10.51298/vmj.v518i2.3458

CARBAMAZEPINE ALLERGY AND ITS ASSOCIATION WITH THE PRESENCE OF HLA-B*15:02 AND HLA-A*31:01 ALLELES IN TAM ANH HOSPITAL

Nguyễn Đoàn Thuỷ1,, Nguyễn Văn Liệu1, Nguyễn Thị Vân Anh2, Chu Văn Sơn2
1 Tâm Anh Hospital
2 Vietnam National University - University of Science

Main Article Content

Abstract

Objective: To evaluate the relationship between Carbamazepine allergy and the presence of HLA-B*15:02 and HLA-A*31:01 alleles in Tam Anh hospital. Subjects and methods: Case-control study conducted in 26 patients allergic with Carbamazepine and 28 patients in control group. Results: A statistically significant association was found between Carbamazepine allergy and HLA-B*15:02 with OR = 4.00 (95%CI 2.28-12.49, p = 0.017). All patients dianosed with Carbamazepine-induced SJS carried HLA-B*15:02. No association was found between Carbamazepine allergy and HLA-A*31:01 with OR = 0.69 (95%CI 0.11-4.53, p = 0.703).

Article Details

Keywords

Allergy, Carbamazepine, HLA-B*15:02, HLA-A*31:01

References

1. Hung S-I, Chung W-H, Jee S-H, Chen W-C, Chang Y-T, Lee W-R, et al. (2006), "Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions", Pharmacogenetics and Genomics 2006 Apr;16(4):297-306.
2. Wu XT, Hu FY, An DM, Yan B, Jiang X, Kwan P, et al. (2010), “Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China”, The New England Journal of Medicine, 364(12):1126–33.
3. Locharernkul C, Loplumlert J, Limotai C, Korkij W, Desudchit T, Tongkobpetch S, et al. (2008), "Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population", Epilepsia. 2008;49(12):2087–91.
4. Khor AH-P, Lim K-S, Tan C-T, Kwan Z, Tan W-C, Wu DB-C, et al. (2017) "HLA-A*31:01 and HLA-B*15:02 association with Stevens–Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population", Pharmacogenetics and Genomics. 2017 Jul;27(7):275.
5. Mark McCormack, Ana Alfirevic, Stephane Bourgeois et al (2011), "HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans", Epilepsy & Behavior 2010 Nov;19(3):405-8.
6. Ozeki T, Mushiroda T, Yowang A, Takahashi A, Kubo M, Shirakata Y, et al. (2011), “Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population”, Human Molecular Genetics 2011 Mar 1;20(5):1034–41.
7. Silje Alvestad, Stian Lydersen, Eylert Brodtkorb (2007), "Rash from antiepileptic drugs: influence by gender, age, and learning disability", Epilepsia 2007;48:1360-5.