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Date Published: 09/10/2022
Abstract Views: 294
Views PDF: 174
DOI: https://doi.org/10.51298/vmj.v518i2.3458
Issue
Vol. 518 No. 2 (2022)
Section
Các bài báo
How to Cite
Đoàn Thuỷ, N. ., Văn Liệu, N. ., Thị Vân Anh, N. ., & Văn Sơn, C. (2022). CARBAMAZEPINE ALLERGY AND ITS ASSOCIATION WITH THE PRESENCE OF HLA-B*15:02 AND HLA-A*31:01 ALLELES IN TAM ANH HOSPITAL. Vietnam Medical Journal, 518(2). https://doi.org/10.51298/vmj.v518i2.3458

CARBAMAZEPINE ALLERGY AND ITS ASSOCIATION WITH THE PRESENCE OF HLA-B*15:02 AND HLA-A*31:01 ALLELES IN TAM ANH HOSPITAL

Nguyễn Đoàn Thuỷ1,, Nguyễn Văn Liệu1, Nguyễn Thị Vân Anh2, Chu Văn Sơn2
1 Tâm Anh Hospital
2 Vietnam National University - University of Science

Main Article Content

Abstract

Objective: To evaluate the relationship between Carbamazepine allergy and the presence of HLA-B*15:02 and HLA-A*31:01 alleles in Tam Anh hospital. Subjects and methods: Case-control study conducted in 26 patients allergic with Carbamazepine and 28 patients in control group. Results: A statistically significant association was found between Carbamazepine allergy and HLA-B*15:02 with OR = 4.00 (95%CI 2.28-12.49, p = 0.017). All patients dianosed with Carbamazepine-induced SJS carried HLA-B*15:02. No association was found between Carbamazepine allergy and HLA-A*31:01 with OR = 0.69 (95%CI 0.11-4.53, p = 0.703).

Article Details

Keywords

Allergy, Carbamazepine, HLA-B*15:02, HLA-A*31:01

References

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