ĐẶC ĐIỂM BỘC LỘ PD-L1 Ở BỆNH NHÂN UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ GIAI ĐOẠN IV TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI

Abstract

Objective: Analysis the correlation of the expression of PD-L1 with characteristics of NSCLC patients with stage IV at Hanoi Medical University Hospital. Patients and methods: Descriptive study on 32 NSCLC patients with stage IV who had PD-L1 test at Medical University Hospital from June 2021 to June 2022. Results: The negative rate of PD-L1 expression was 53.1%, 25.0% of the cases had intermediate (1-49%), and the rate of high positive (≥ 50%) was 21.9%. The rate of positive PD-L1 expression was higher in the group of ≥50 years old, female (55.6%) was higher than male (43.5%), the smokers (56.2%) was higher than the non-smoker (37.5%), the sampling site of the primary lung tumor (47.1%) was higher than the cell block of pleural fluid or distant organ metastasis, although there were no statistically significant differences with p>0.05. There was no relationship between PD-L1 expression rate and specimen collection method, number of metastatic organs, EGFR mutation, or NLR ratio. Conclusions: The NSCLC patients with stage IV have a relatively high rate of PD-L1 positivity, even in the absence of EGFR gene mutations.