Article Sidebar

PDF
Date Published: 09/10/2022
Abstract Views: 191
Views PDF: 99
DOI: https://doi.org/10.51298/vmj.v518i2.3473
Issue
Vol. 518 No. 2 (2022)
Section
Các bài báo
How to Cite
DAOCHAITONGYOUATHAO, V. ., & Quang Minh, P. . (2022). ASSESSMENT OF THE EFFECTS OF GRANISETRON VARIOUS ONDANSETRON IN PREVENTION OF SOME ADVERSE EFFECTS OF SPINAL ANESTHESIA IN LOWER EXTREMITY SURGERY. Vietnam Medical Journal, 518(2). https://doi.org/10.51298/vmj.v518i2.3473

ASSESSMENT OF THE EFFECTS OF GRANISETRON VARIOUS ONDANSETRON IN PREVENTION OF SOME ADVERSE EFFECTS OF SPINAL ANESTHESIA IN LOWER EXTREMITY SURGERY

Vongvien DAOCHAITONGYOUATHAO1,, Phạm Quang Minh2
1 5 Mesa Hospital, Laos
2 Hanoi Medical University Hospital

Main Article Content

Abstract

A randomized clinical trial research was conducted to compare the efficacy of granisetron versus ondansetron in the prevention of some undesirable effects of spinal anesthesia in lower extremity surgery. 60 patients, divided into 2 groups, underwent lower extremity surgery and were anesthesia by spinal anesthesia at Hanoi Medical University Hospital from January to June 2022. Result: some anthropometric indices, kind of surgeries were equivalent in the 2 groups. After spinal induction, the granisetron group had a 0,24 times reduction in nausea or vomiting compared with the ondansetron, the difference was not statistically significant between the 2 groups with p ˃ 0,05. Hemodynamic:  the granisetron group had a much more stable heart rate than the ondansetron, the difference was not statistically significant with p ˃ 0,05. The risk of hypotension in the granisetron group decreased by 4,5 times compared with the ondansetron, the difference was statistically significant with p ˂ 0,05. Conclusions: Granisetron is more effective than ondansetron in prevention of some adverse effects of spinal anesthesia in lower extremity surgery.

Article Details

Keywords

Spinal anesthesia, granisetron, ondansetron, lower extremity surgery

References

1. Hoàng Thị Thu Hà. Đánh giá hiệu quả của Ondansetron trong dự phòng một số tác dụng không mong muốn của gây tê tủy sống trong phẫu thuật chi dưới, Trường Đại học Y Hà Nội; 2020.
2. Bucklin B.A., Hawkins J.L., Anderson J.R., Ullrich F.A. Obstetric anesthesia workforce survey: a twenty-year update. The Journal of the American Society of Anesthesiologists. 2005; 103(3): 645-653.
4. Leeser J., Lip H. Prevention of postoperative nausea and vomiting using ondansetron, a new, selective 5-HT3 receptor antagonist. Anesthesia and analgesia. 1991; 72(6): 751-755.
3. Kim EJ, Ko Js, Kim CS, Lee SM, Choi DH. Combination of Antiemetics for the Prevention of Postoperative Nausea and Vomiting in High-Risk Patients. J Korean Med Sci.2007;22(5):878-882.
5. Owcsuk R, Wenski W, Polak-Krzeminska A, et al. Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: a double-blind, placebo-controlled study. Reg Anesth Pain Med. 2008;33(4):332-339
6. Sahoo T, SenDasgupta C, Goswami A, Hazra A. Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. Int J Obstet Anesth. 2012;21(1):24-28.
7. Shahriari A., Khooshideh M., Heidari M.H. Prevention of nausea and vomiting in the cesarean section under spinal anesthesia with midazolam or metoclopramide. J Pak Med Assoc. 2009; 59(11): 756-759.
8. Sharma SP, Raghu K, Nikhi N, Rajaram G, Kumar S, Singh S. Prophylactic adminisyration of ondansetron for caesarean section. Cochrane Database Syst Rew. 2017;2017(8).