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Date Published: 09/10/2022
Abstract Views: 242
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DOI: https://doi.org/10.51298/vmj.v518i2.3473
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Vol. 518 No. 2 (2022)
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DAOCHAITONGYOUATHAO, V. ., & Quang Minh, P. . (2022). ASSESSMENT OF THE EFFECTS OF GRANISETRON VARIOUS ONDANSETRON IN PREVENTION OF SOME ADVERSE EFFECTS OF SPINAL ANESTHESIA IN LOWER EXTREMITY SURGERY. Vietnam Medical Journal, 518(2). https://doi.org/10.51298/vmj.v518i2.3473

ASSESSMENT OF THE EFFECTS OF GRANISETRON VARIOUS ONDANSETRON IN PREVENTION OF SOME ADVERSE EFFECTS OF SPINAL ANESTHESIA IN LOWER EXTREMITY SURGERY

Vongvien DAOCHAITONGYOUATHAO1,, Phạm Quang Minh2
1 5 Mesa Hospital, Laos
2 Hanoi Medical University Hospital

Main Article Content

Abstract

A randomized clinical trial research was conducted to compare the efficacy of granisetron versus ondansetron in the prevention of some undesirable effects of spinal anesthesia in lower extremity surgery. 60 patients, divided into 2 groups, underwent lower extremity surgery and were anesthesia by spinal anesthesia at Hanoi Medical University Hospital from January to June 2022. Result: some anthropometric indices, kind of surgeries were equivalent in the 2 groups. After spinal induction, the granisetron group had a 0,24 times reduction in nausea or vomiting compared with the ondansetron, the difference was not statistically significant between the 2 groups with p ˃ 0,05. Hemodynamic:  the granisetron group had a much more stable heart rate than the ondansetron, the difference was not statistically significant with p ˃ 0,05. The risk of hypotension in the granisetron group decreased by 4,5 times compared with the ondansetron, the difference was statistically significant with p ˂ 0,05. Conclusions: Granisetron is more effective than ondansetron in prevention of some adverse effects of spinal anesthesia in lower extremity surgery.

Article Details

Keywords

Spinal anesthesia, granisetron, ondansetron, lower extremity surgery

References

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