Article Sidebar

PDF
Date Published: 09/10/2022
Abstract Views: 589
Views PDF: 256
DOI: https://doi.org/10.51298/vmj.v518i2.3486
Issue
Vol. 518 No. 2 (2022)
Section
Các bài báo
How to Cite
Thị Tuyết Nga, P. ., & Huyền Trang, N. . (2022). PREPARATION OF CHLORHEXIDINE 2% ORAL ANTISEPTIC SOLUTION AND SOME CHARACTERISTICS OF THE PRODUCT IN THE LABORATORY. Vietnam Medical Journal, 518(2). https://doi.org/10.51298/vmj.v518i2.3486

PREPARATION OF CHLORHEXIDINE 2% ORAL ANTISEPTIC SOLUTION AND SOME CHARACTERISTICS OF THE PRODUCT IN THE LABORATORY

Phạm Thị Tuyết Nga1, Nguyễn Huyền Trang1,
1 The Odonto-Stomatology Training Institute, Hanoi Medical University

Main Article Content

Abstract

Chlorhexidine is an antiseptic effective against gram-negative, gram-positive bacteria and other micro organisms. Our research is done on prepared products Chlorhexidine 2% with the aim of finding out which one is the optimal formula and evaluate the physicochemical properties of the product in the laboratory. Result: Chlorhexidine 2% after preparation exists in liquid; blue color; characteristic taste; does not separate into layers and precipitates at 10-45 degrees Celsius; Chlorhexidine concentration is 1.8 %; indicators of heavy metals Arsenic (As) is 0.31ppm, lead (Pb) is 0.72ppm, mecury (Hg) is 0.19ppm. Conclusion: Prepared Chlorhexidine 2% achieves stability, safety, and organoleptic properties consistent with the requirements of a product for public use.

Article Details

Keywords

Chlorhexidine, antiseptic

References

1. Leikin, Jerrold.B, Paloucek et al (2008). Chlorhexidine Gluconate, Poisoning and Toxicology Handbook ,4th edition, 183-184
2. Trung tâm Dược điển – Dược thư Việt Nam (2018). Dược thư quốc gia Việt Nam, lần xuất bản thứ 2, Nhà xuất bản y học Hà Nội,1166
3. Kuyyakanond T, Quesnel LB (1992). The mechanism of action of chlorhexidine, FEMS Microbiol Lett, 100(1-3):211-5
4. Wade, Ryckie G, Burr, Nicholas E et al (2020). The Comparative Efficacy of Chlorhexidine Gluconate and Povidone-iodine Antiseptics for the Prevention of Infection in Clean Surgery: A Systematic Review and Network Meta-analysis. Annals of Surgery.
5.Rahimi S, Lazarou G(2010). Late – onset allergic reaction to poividone iodine resulting in vular edema and urinary retention. Obstet Gynecol, 116(2): 56204
6. Luật Việt Nam. Tiêu chuẩn TCVN 5816:2009 Sản phẩm vệ sinh răng nha khoa.
7. Phương pháp quang phổ nguyên tử phát xạ và hấp thụ - Dược Điển Việt Nam