TÌNH HÌNH ĐỀ KHÁNG KHÁNG SINH CỦA KLEBSIELLA PNEUMONIA TẠI BỆNH VIỆN ĐA KHOA TRUNG ƯƠNG CẦN THƠ

Abstract

Background: Klebsiella pneumoniae is known to be a common cause of infection, but it can be very severe and has a high rate of antibiotic resistance. Providing information on antibiotic resistance of Klebsiella pneumoniae is essential for clinical practice. Objectives: To evaluate antibiotic resistance of Klebsiella pneumoniaat at Can Tho Central General Hospital. Subjects and methods: A cross-sectional descriptive study was conducted on 387 isolates of Klebsiella pneumoniae from clinical specimens of septic patients at Can Tho Central General Hospital from 01/2019 to 08/2019. Conducting bacterial identification, Antibiogram and ESBL testing by using the Vitek 2 compact system. Result: Klebsiella pneumoniae was the most resistant to ampicillin with the rate of 97.4% (377/387). Next is ampicillin/ sulbactam with 84% (325/387). The sensitivity rate in Fluoroquinolones and Nitrofurans antibiotic groups is also low, only 14.2% - 19.4%. For the Carbapenems group, the medium resistance ranged from 35.9% to 40.3%. The antibiotic with the lowest resistance rate was amikacin with 3.1% (12/387). However, the remaining antibiotics in the Aminoglycosides group had a medium resistance level of 46.3% - 49.4%. The rate of multidrug-resistant Klebsiella pneumoniae was 89.1% (345/387) and ESBL-producing Klebsiella pneumoniae was 31.3% (121/387). ESBL-producing Klebsiella pneumoniae strains have higher antibiotic resistance rates than non-ESBL-producing strains. Conclusion: The Klebsiella pneumoniae strains in our study have quite high rates of antibiotic resistance and multidrug-resistant. The rate of ESBL-producing Klebsiella pneumoniae was in medium level and affected the antibiotic resistance of bacterial strains.