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Date Published: 17/10/2022
Abstract Views: 336
Views PDF: 152
DOI: https://doi.org/10.51298/vmj.v519i1.3505
Issue
Vol. 519 No. 1 (2022)
Section
Các bài báo
How to Cite
Thái Dương, P. ., & Quang Toản, V. . (2022). EFFECTIVENESS OF BEP CHEMOTHERAPY REGIMEN IN TREATMENT OF METASTATIC TESTICULAR CANCER. Vietnam Medical Journal, 519(1). https://doi.org/10.51298/vmj.v519i1.3505

EFFECTIVENESS OF BEP CHEMOTHERAPY REGIMEN IN TREATMENT OF METASTATIC TESTICULAR CANCER

Phạm Thái Dương1,, Vũ Quang Toản2
1 Hanoi Medical University
2 Vietnam National Cancer Hospital

Main Article Content

Abstract

Objective: To evaluate the efficacy and safety profile of BEP chemotherapy regimen in patients with metastatic testicular cancer. Patients and method: Restropective and prospective description study of 36 patients with metastatic testicular cancer who received bleomycin, etoposide, and cisplatin chemotherapy at K hospital from 1/2014 to 6/2022. Results: Disease Control Rate is 79,6%. There was 22,2% case with complete respond. The partly respond is 55,7%, stable disease is 2,8%. The incidence of leukopenia in grade 3 and grade 4 is 33,3% and 22,9%. Erythrocytopenia was seen in 47,2% of cases, all is grade 1 and 2. Liver and kidney toxicity is uncommon and mostly is grade 1 and 2. The mean overall survival is 75,5 ± 5,7. Five-year survival rate is 77,8%. Conclusions: BEP (bleomycin, etoposide, cisplatin) is an effective chemotherapeutic regimen for metastatic testicular cancer  patients.

Article Details

Keywords

metastatic testicular cancer, BEP, toxicity

References

1. Motzer R.J., Agarwal N., Beard C. và cộng sự. (2009). Testicular Cancer. J Natl Compr Canc Netw, 7(6), 672–693.
2. Cấn Xuân Hạnh: Đánh giá kết quả điều trị ung thư tinh hoàn tại bệnh viện K từ 2005 đến 2013. 2014.
3. Hanna N. và Einhorn L.H. (2014). Testicular cancer: a reflection on 50 years of discovery. J Clin Oncol, 32(28), 3085–3092.
4. Woldu S.L. và Bagrodia A. (2018). Update on epidemiologic considerations and treatment trends in testicular cancer. Current Opinion in Urology, 28(5), 440–447.
5. Culine S., Kramar A., Théodore C. và cộng sự. (2008). Randomized Trial Comparing Bleomycin/Etoposide/Cisplatin With Alternating Cisplatin/Cyclophosphamide/Doxorubicin and Vinblastine/Bleomycin Regimens of Chemotherapy for Patients With Intermediate- and Poor-Risk Metastatic Nonseminomatous Germ Cell Tumors: Genito-Urinary Group of the French Federation of Cancer Centers Trial T93MP. JCO, 26(3), 421–427.
6. de Wit R., Stoter G., Sleijfer D.T. và cộng sự. (1995). Four cycles of BEP versus an alternating regime of PVB and BEP in patients with poor-prognosis metastatic testicular non-seminoma; a randomised study of the EORTC Genitourinary Tract Cancer Cooperative Group. Br J Cancer, 71(6), 1311–1314.
7. Madan R., Thakur N., Rana S. và cộng sự. (2019). Impact of the modified bleomycin, etoposide and cisplatinum chemotherapy regimen on the outcome of testicular germ cell tumor: a tertiary care institute experience. Int Surg J, 6(9), 3305.