KHẢO SÁT VÀ ĐỊNH DANH KHÁNG THỂ BẤT THƯỜNG Ở NHỮNG SẢN PHỤ CÓ TIỀN CĂN SẢY THAI

Abstract

Background: There are many causes for miscarriage such as chromosomal abnormalities, autoimmune diseases, etc… One of which is due to unexpected antibodies, which is the leading cause for hemolytic disease of fetus and newborn. Unexpected antibody screening serves to manage pregnancy outcome but there has not been any research on the rate of unexpected antibody in pregnant women in Vietnam. Objective: The aim of the study is to determine the rate of unexpected antibodies in pregnant women at Hung Vuong hospital from February 2022 to August 2022. Methods: Pregnant women consented to participate in the study for prenatal testing at an obstetrics clinic in a single center were divided into two groups. One is a control group, which contains patients who do not have any previous miscarriage. The other group is the cases group which contains women who had previous miscarriage. All pregnant women participating in the study underwent irregular antibody screening. Those who screened positive for irregular antibodies were tested with antibody identification. Result: The prevalence of unexpected antibody is 0,59% (3/507). The prevalence of unexpected antibody in pregnant women who had previous miscarriage is 0,59% (2/338). The prevalence of unexpected antibody in control group is 0,59% (1/169). Multiple types of unexpected antibody accounted for 66,67% of positive unexpected antibody screening cases and the found antibodies are Anti E, Anti M, Anti Le^a, Anti K. Conclusion: Unexpected antibody screening for all pregnant women following Western countries’ policy can not be apllied to Vietnam due to cost and the prevalence of unexpected antibody. Therefore, we propose unexpected antibody screening for pregnant women who is multigravida or had previous history of miscarriage, hemolytic disease of fetus and newborn, previous hyperbilurubinemia newborn, blood tranfusion.