NGHIÊN CỨU XÂY DỰNG QUY TRÌNH ĐỊNH LƯỢNG QUERCETIN TRONG THỰC PHẨM BẢO VỆ SỨC KHỎE VÀ THUỐC BẰNG SẮC KÝ LỎNG HIỆU NĂNG CAO

Abstract

Flavonoids are a large group of compounds commonly found in plants. Quercetin is a Flavonoid, which has been studied for its ability to reduce the risk of cardiovascular diseases, prevent the development of cancer, reduce allergies and relieve pain for gout... Currently, Quercetin is used quite a lot. widely available mainly in the form of functional foods and available on the pharmaceutical market with different dosage forms: Tablets, capsules, powder.... Currently, in the pharmacopoeias, there is no official monograph for the qualitative and quantitative quercetin. Therefore, in order to improve the effectiveness of drug quality monitoring for public health, the research team conducted the topic Objective: To study and build a process to quantify Quercetin in TPBVSK and drugs derived from and apply the established process to quantify Quercetin in some products currently circulating in Ha Tinh province. Subjects and research methods: Some health-protective foods and drugs derived from medicinal herbs collected in the locality of Ha Tinh province. Quercetin was determined by high performance liquid chromatography. Results: The quantification process of quercetin has been developed by high-performance liquid chromatography. The analytical procedure was quality controlled and highly repeatable with RSD < 2.0% (n = 9); achieved good accuracy with recovery from 103.9% - 119.6%. Successfully applied the construction process to analyze quercetin in 4 samples including traditional medicines and TPBVSK circulating on the market in Ha Tinh province. Conclusion: Developing a process to quantify quercetin content in health foods and drugs of medicinal origin.