QUALITY OF BOWEL PREPARATION FOR COLONOSCOPY BY COMBINING SIMETHICONE WITH FORTRANS AT HANOI MEDICAL UNIVERSITY HOSPITAL

Lương Thị Mai Hương1,, Đào Viết Quân1, Trần Quốc Tiến1, Đào Việt Hằng1,2, Lê Quang Hưng1, Nguyễn Thị Thảo1, Hoàng Bảo Long3, Vũ Thị Vựng3, Lâm Ngọc Hoa3, Đào Văn Long1,2
1 Endoscopy Center, Hanoi Medical University Hospital
2 Hanoi Medical University
3 The Institute of Gastroenterology and Hepatology

Main Article Content

Abstract

This randomized controlled trial determined the quality of bowel cleansing when combining with simethicone. Patients who would undergo total colonoscopy on the same day of checkup were randomly assigned to intervention (with simethicone) or control arm  (without simethicone) and quality of bowel cleansing was assessed by the McNally scale. Among 380 participants, 192 were assigned to the intervention arm. The proportion of patients who completed the regimen for bowel preparation with the instructed duration (2-3 hours) was higher in the intervention arm than in the control carm (53.7% vs. 41.5%, p=0.04). The proportion of self-report clean bowel preparation was higher in the intervention arm (99% vs. 91%, p=0.03). The proportion of good bowel cleansing in the intervention arm (100%) was higher in the control arm (around 40%) in all three colon segments. In this trial, adding simethicone to bowel preparation improved the effectiveness of bowel preparation.

Article Details

References

1. Bộ y tế, Dược thư quốc gia Việt Nam, Nhà xuất bản Y học (2018):1291-1292
2. Đào Viết Quân, Đỗ Thị Việt Phương, Hoàng Anh Tú, Đánh giá hiệu quả làm sạch của Fleet phosphor soda so với Fortrans trên người bệnh có chỉ định nội soi đại tràng tại Bệnh viện Đại học Y Hà Nội. 2017, Đề tài cơ sở Bệnh viện Đại học Y Hà Nội.
3. Trần Lý Thảo Vy. Nghiên cứu hiệu quả tan bọt của simethicone trong chuẩn bị nội soi tiêu hóa dưới. Tạp chí Y học thành phố Hồ Chí Minh. 2019; tập 23 – số 1.
4. David Kastenberg, MD et all. The Effect on Colon Visualization During Colonoscopy of the Addition of simethicone to Polyethylene Glycol- Electrolyte Solution: A Randomized Single-Blind Study. Clinical and Translational Gastroenterology volume3, page26 (2012).
5. McNally PR, Maydonovitch CL et all. The effect of simethicone on colonic visibility after night-prior colonic lavage. A double-blind randomized study. J Clin Gastroenterol. 1989;11:650–652.
6. Tongprasert S, Sobhonslidsuk A, Rattanasiri S. Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation. World J Gastroenterol 2009; 15: 3032–3037.
7. Chan, W.K, et all. Appointment waiting times and education level influence the quality of bowel preparation in adult patients undergoing colonoscopy. BMC Gastroenterol 2011; 28;11:86.